Skp2 inhibitor 2

• 常用名: Skp2 inhibitor 2
• 英文名: Skp2 inhibitor 2
• CAS号: 2760612-77-7
• 分子量: 428.57
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₂N₄O
• 熔点: N/A
• 闪点: N/A

Skp2 inhibitor 2用途

Skp2抑制剂2(14f)是F-box蛋白S期激酶相关蛋白2(Skp2)的抑制剂,IC50值为10.2μM(Skp2-Cks1)。Skp2是cullin-RING连接酶的一部分,其募集和泛素化底物,参与蛋白水解和非蛋白水解过程[1]。

Skp2 inhibitor 2名称

• 英文名: Skp2 inhibitor 2

Skp2 inhibitor 2生物活性

• 描述: Skp2抑制剂2(14f)是F-box蛋白S期激酶相关蛋白2(Skp2)的抑制剂,IC50值为10.2μM(Skp2-Cks1)。Skp2是cullin-RING连接酶的一部分,其募集和泛素化底物,参与蛋白水解和非蛋白水解过程[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> E1/E2/E3酶
• 靶点实验:

  cullin-RING ligases[1]

• 参考文献:

  [1]. Zhang K, et al. Discovery of Novel 1,3-Diphenylpyrazine Derivatives as Potent S-Phase Kinase-Associated Protein 2 (Skp2) Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Jun 8;66(11):7221-7242.

Skp2 inhibitor 2物理化学性质

• 分子式: C₂₇H₃₂N₄O
• 分子量: 428.57

Skp2 inhibitor 2靶点实验

查看更多实验

实验名称：Antitumor activity against human PC-3 cells assessed as cell growth inhibition incuba... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL5342863

实验名称：Solubility in cell culture medium by HPLC analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL5342864

实验名称：Antitumor activity against human MCF7 cells assessed as cell growth inhibition incuba... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL5342861

实验名称：Antitumor activity against human EC1 cells assessed as cell growth inhibition incubat... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5342862

实验名称：Antitumor activity against human MGC-803 cells assessed as cell growth inhibition inc... 来源：ChEMBL 靶标：MGC-803 External Id：CHEMBL5342859

实验名称：Antitumor activity against human NCI-H1299 cells assessed as cell growth inhibition i... 来源：ChEMBL 靶标：NCI-H1299 External Id：CHEMBL5342860

实验名称：Inhibition of GST-tagged Skp2/Skp1 (unknown origin)/His6-tagged Cks1 (unknown origin)... 来源：ChEMBL 靶标：S-phase kinase-associated protein 1 External Id：CHEMBL5342858

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