Geniposidic acid
Modify Date: 2024-01-02 13:15:30
Geniposidic acid structure
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Common Name | Geniposidic acid | ||
|---|---|---|---|---|
| CAS Number | 27741-01-1 | Molecular Weight | 374.340 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 684.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H22O10 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 250.9±25.0 °C | |
Use of Geniposidic acidGeniposidic acid is an effective anticancer and radioprotection agent.Target: OthersMice were given an intraperitoneal injection of Geniposidic acid (GA) (12.5, 25, 50 mg/kg) 1 h before receiving GA against d-galactosamine (GalN) (800 mg/kg)/LPS (40 μg/kg). Liver and blood samples were collected 1 and 8 h after GalN/LPS injection. The survival rate of the GA group was significantly higher than the control. GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreased hepatic glutathione content [1]. GA enhanced significantly the postirradiation responses of splenic blastogenesis by PHA. In addition, GA is a potent tumor growth inhibitor when combined with the X-irradiation, though there was no significant synergetic effect on their combined antitumor activity. The preliminary results of GA on hematological and blastogenic observations in this study suggested that it may very well, partially, play a role in an effective anticancer product with the ability to decrease undesirable radiation damage to the hematologic tissue after high dose irradiation [2]. |
| Name | (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
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| Synonym | More Synonyms |
| Description | Geniposidic acid is an effective anticancer and radioprotection agent.Target: OthersMice were given an intraperitoneal injection of Geniposidic acid (GA) (12.5, 25, 50 mg/kg) 1 h before receiving GA against d-galactosamine (GalN) (800 mg/kg)/LPS (40 μg/kg). Liver and blood samples were collected 1 and 8 h after GalN/LPS injection. The survival rate of the GA group was significantly higher than the control. GalN/LPS increased serum aminotransferase activity, serum tumor necrosis factor-α level and hepatic lipid peroxidation and decreased hepatic glutathione content [1]. GA enhanced significantly the postirradiation responses of splenic blastogenesis by PHA. In addition, GA is a potent tumor growth inhibitor when combined with the X-irradiation, though there was no significant synergetic effect on their combined antitumor activity. The preliminary results of GA on hematological and blastogenic observations in this study suggested that it may very well, partially, play a role in an effective anticancer product with the ability to decrease undesirable radiation damage to the hematologic tissue after high dose irradiation [2]. |
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| Related Catalog | |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 684.1±55.0 °C at 760 mmHg |
| Molecular Formula | C16H22O10 |
| Molecular Weight | 374.340 |
| Flash Point | 250.9±25.0 °C |
| Exact Mass | 374.121307 |
| PSA | 166.14000 |
| LogP | -1.68 |
| Vapour Pressure | 0.0±4.8 mmHg at 25°C |
| Index of Refraction | 1.660 |
| Storage condition | 2~8℃ |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
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Geniposidic acid CAS#:27741-01-1 |
| Literature: Jones, Regan A.; Krische, Michael J. Organic Letters, 2009 , vol. 11, # 8 p. 1849 - 1851 |
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Geniposidic acid CAS#:27741-01-1 |
| Literature: Mi, Fwu-Long; Huang, Chin-Tsung; Liang, Hsiang-Fa; Chen, Mei-Chin; Chiu, Ya-Ling; Chen, Chun-Hung; Sung, Hsing-Wen Journal of Agricultural and Food Chemistry, 2006 , vol. 54, # 9 p. 3290 - 3296 |
![7-(2,2-dimethyl-propionyloxymethyl)-1-(3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yloxy)-1,4a,5,7a-tetrahydro-cyclopenta[c]pyran-4-carboxylic acid methyl ester structure](https://image.chemsrc.com/caspic/370/1141938-70-6.png)
| Precursor 2 | |
|---|---|
| DownStream 1 | |
| (1S,4aS,7aS)-1-(β-D-Glucopyranosyloxy)-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
| (1R,2S,6S)-9-(HYDROXYMETHYL)-2-[(2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)OXAN-2-YL]OXY-3-OXABICYCLO[4.3.0]NONA-4,8-DIENE-5-CARBOXYLIC ACID |
| Geniposidinsaeure |
| Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, (1S,4aS,7aS)- |
| geniposidic acid |
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