1,12-Diaminododecane

Modify Date: 2024-01-02 13:30:59

1,12-Diaminododecane Structure
1,12-Diaminododecane structure
Common Name 1,12-Diaminododecane
CAS Number 2783-17-7 Molecular Weight 200.364
Density 0.9±0.1 g/cm3 Boiling Point 274.9±8.0 °C at 760 mmHg
Molecular Formula C12H28N2 Melting Point 67-69 °C(lit.)
MSDS Chinese USA Flash Point 155.0±0.0 °C
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of 1,12-Diaminododecane


N12N is a polyamine inverse agonist of NMDA receptor.

 Names

Name dodecane-1,12-diamine
Synonym More Synonyms

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 274.9±8.0 °C at 760 mmHg
Melting Point 67-69 °C(lit.)
Molecular Formula C12H28N2
Molecular Weight 200.364
Flash Point 155.0±0.0 °C
Exact Mass 200.225250
PSA 52.04000
LogP 3.23
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.465

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JR2200000
CHEMICAL NAME :
1,12-Dodecanediamine
CAS REGISTRY NUMBER :
2783-17-7
BEILSTEIN REFERENCE NO. :
1742765
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H28-N2
MOLECULAR WEIGHT :
200.42
WISWESSER LINE NOTATION :
Z12Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
670 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 1,92,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1088 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
330 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
54600 ug/kg/26W-I
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - change in clotting factors Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 43(5),18,1978

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302-H314-H317
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C: Corrosive;
Risk Phrases R22;R36/37/38
Safety Phrases S26-S36/37/39-S45
RIDADR UN 3259 8/PG 3
WGK Germany 1
RTECS JR2200000
Packaging Group I; II; III
Hazard Class 8.0
HS Code 2921290000

 Synthetic Route

~54%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: Bartoli, Giuseppe; Di Antonio, Giustino; Giovannini, Riccardo; Giuli, Sandra; Lanari, Silvia; Paoletti, Melissa; Marcantoni, Enrico Journal of Organic Chemistry, 2008 , vol. 73, # 5 p. 1919 - 1924

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: Saotome,K. et al. Bulletin of the Chemical Society of Japan, 1966 , vol. 39, p. 480 - 484

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: Saotome,K. et al. Bulletin of the Chemical Society of Japan, 1966 , vol. 39, p. 480 - 484

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: Saotome,K. et al. Bulletin of the Chemical Society of Japan, 1966 , vol. 39, p. 480 - 484

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: Chemie Linz GmbH Patent: US5475141 A1, 1995 ;

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: v. Braun; Anton Chemische Berichte, 1931 , vol. 64, p. 2867

~%

1,12-Diaminododecane Structure

1,12-Diaminododecane

CAS#:2783-17-7

Literature: v. Braun Chemische Berichte, 1909 , vol. 42, p. 4548

 Customs

HS Code 2921290000
Summary 2921290000 other acyclic polyamines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

1,12-dodecadiamine
1,12-DODECANEDIAME
Diaminododecane
1,12-diaminododecyl
DODECANEDIAMINE
1,12-dodecamethylenediamine
RARECHEM AL BW 0116
Dodecamethylendiamin
dodecane-1,12-diamine
dodecyldiamine
EINECS 220-489-6
1,12-Diaminododecane
Decanethylenediamine
1,12-diamino dodecane
Dodecamethylenediamine
MFCD00008155
1,12-Dodecanediamine
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