Orientin

Modify Date: 2024-01-02 13:56:51

Orientin Structure
Orientin structure
Common Name Orientin
CAS Number 28608-75-5 Molecular Weight 448.377
Density 1.8±0.1 g/cm3 Boiling Point 816.1±65.0 °C at 760 mmHg
Molecular Formula C21H20O11 Melting Point 260-285ºC
MSDS Chinese USA Flash Point 289.1±27.8 °C

 Use of Orientin


Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].

 Names

Name Orientine
Synonym More Synonyms

 Orientin Biological Activity

Description Orientin is a naturally occurring bioactive flavonoid that possesses diverse biological properties, including anti-inflammation, anti-oxidative, anti-tumor, and cardio protection. Orientin is a promising neuroprotective agent suitable for therapy for neuropathic pain[1][2].
Related Catalog
References

[1]. Dhakal H, et al. Inhibitory effects of orientin in mast cell-mediated allergic inflammation. Pharmacol Rep. 2020 Jan 24.

[2]. Guo D, et al. Orientin and neuropathic pain in rats with spinal nerve ligation. 61Int Immunopharmacol. 2018 May;58:72-79.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Boiling Point 816.1±65.0 °C at 760 mmHg
Melting Point 260-285ºC
Molecular Formula C21H20O11
Molecular Weight 448.377
Flash Point 289.1±27.8 °C
Exact Mass 448.100555
PSA 201.28000
LogP 1.58
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.767
Storage condition 2~8°C
Water Solubility 1 M NaOH: soluble1mg/mL, clear, yellow-orange

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DJ3009300
CHEMICAL NAME :
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-beta-D-glucopyranosyl-5,7-d ihydroxy-
CAS REGISTRY NUMBER :
28608-75-5
LAST UPDATED :
199106
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H20-O11
MOLECULAR WEIGHT :
448.41

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
50 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 246,205,1991

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
RTECS DJ3009300

 Articles25

More Articles
Distinction of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin using HPLC-MS exact mass measurement and in-source CID.

Phytochem. Anal. 16(5) , 295-301, (2005)

HPLC-MS using collision induced dissociation (CID) has been utilised for the identification of the C-glycosylflavone isomer pairs orientin/isoorientin and vitexin/isovitexin. HPLC-CID/MS analyses prod...

Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.

Pharm. Biol. 50(11) , 1428-35, (2012)

Lagenaria siceraria (Molina) Standl. (Cucurbitacae) (LS) has been reported to possess cardioprotective, antihyperlipidemic, and diuretic activities.To evaluate antihypertensive and cardioprotective ef...

Development and validation of an HPTLC method for simultaneous quantitation of isoorientin, isovitexin, orientin, and vitexin in bamboo-leaf flavonoids.

J. AOAC Int. 93(5) , 1376-83, (2010)

A simple HPTLC method has been developed for the simultaneous determination of isoorientin, isovitexin, orientin, and vitexin, both pure and in commercial samples of bamboo-leaf flavonoids. The flavon...

 Synonyms

isoorientin
(1S)-1,5-Anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-8-yl]-D-glucitol
2-(3,4-Dihydroxyphényl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxyméthyl)tétrahydro-2H-pyran-2-yl]-4H-chromén-4-one
Orientin 8-C-β-D-glucopyranoside
3',4',5,7-tetrahydroxyflavone-8-C-glucoside
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-on
Luteolin-8-C-glucoside
3',4',5,7-tetrahydroxyflavone 8-glucoside
4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-8-β-D-glucopyranosyl-5,7-dihydroxy-
D-Glucitol, 1,5-anhydro-1-C-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-1-benzopyran-8-yl]-, (1S)-
Orientin
lutexin
2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-4H-chromen-4-one
2-(3,4-Dihydroxyphenyl)-8-b-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one
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