JMJD3/HDAC-IN-1

Modify Date: 2024-01-23 15:58:53

JMJD3/HDAC-IN-1 structure	Common Name	JMJD3/HDAC-IN-1
	CAS Number	2883046-06-6	Molecular Weight	398.50
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₃₀N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JMJD3/HDAC-IN-1

JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].

Name	JMJD3/HDAC-IN-1

Description	JMJD3/HDAC-IN-1 (compound A5b) is a dual inhibitor targeting Jumonji domain-containing protein demethylase 3 (JMJD3) and histone deacetylase (HADC1, IC50=16 nM). JMJD3/HDAC-IN-1 promotes hypermethylation of histone H3K27 and hyperacetylation of H3K9, and also cleaves caspase-7 and PARP to induce apoptosis. JMJD3/HDAC-IN-1 effectively inhibits cancer cell cloning, migration, and invasion[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	IC50: 16 nM (HDAC1), 534 nM (HDAC6)[1]
References	[1]. Li A, et al. Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors. Bioorg Med Chem Lett. 2023 Oct 1;94:129466.. .

Molecular Formula	C₂₁H₃₀N₆O₂
Molecular Weight	398.50

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

JMJD3/HDAC-IN-1

Use of JMJD3/HDAC-IN-1

Names

JMJD3/HDAC-IN-1 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.