α-Hydroxyglutaric acid
Modify Date: 2024-01-02 18:56:15
α-Hydroxyglutaric acid structure
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Common Name | α-Hydroxyglutaric acid | ||
|---|---|---|---|---|
| CAS Number | 2889-31-8 | Molecular Weight | 146.09800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H6O5-- | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of α-Hydroxyglutaric acidα-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1]. |
| Name | 2-hydroxyglutaric acid |
|---|---|
| Synonym | More Synonyms |
| Description | α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1]. |
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| Related Catalog | |
| In Vitro | Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases[1]. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin[1]. |
| References |
| Molecular Formula | C5H6O5-- |
|---|---|
| Molecular Weight | 146.09800 |
| Exact Mass | 146.02200 |
| PSA | 100.49000 |
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