SWS1

• 常用名: SWS1
• 英文名: SWS1
• CAS号: 2922115-32-8
• 分子量: 849.48
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₇H₅₃ClN₆O₅S
• 熔点: N/A
• 闪点: N/A

SWS1用途

SWS1 是一种 d-(+)-生物素缀合的 PD-L1 抑制剂 (IC50: 1.8 nM),具有抗癌活性。SWS1 能够增加肿瘤浸润淋巴细胞的数量,在 B16-F10 小鼠模型中表现出抗肿瘤功效 (TGI=66.1%)。

SWS1名称

• 英文名: SWS1

SWS1生物活性

• 描述: SWS1 是一种 d-(+)-生物素缀合的 PD-L1 抑制剂 (IC50: 1.8 nM),具有抗癌活性。SWS1 能够增加肿瘤浸润淋巴细胞的数量,在 B16-F10 小鼠模型中表现出抗肿瘤功效 (TGI=66.1%)。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 神经信号通路 >> 单胺氧化酶
  信号通路 >> 免疫及炎症 >> PD-1/PD-L1
• 靶点实验:

  IC50: 1.8 nM (PD-1/PD-L1)[1]

• 参考文献:

  [1]. Ding Z, et al. Discovery of Novel d-(+)-Biotin-Conjugated Resorcinol Dibenzyl Ether-Based PD-L1 Inhibitors for Targeted Cancer Immunotherapy. J Med Chem. 2023 Aug 10;66(15):10364-10380..

SWS1物理化学性质

• 分子式: C₄₇H₅₃ClN₆O₅S
• 分子量: 849.48
• InChIKey: YCHPIMKSTJPEFJ-PXMSFUJDSA-N
• SMILES: Cc1c(COc2cc(OCc3cccc(C#N)c3)c(CN3CCCCC3C(=O)NCCNC(=O)CCCCC3SCC4NC(=O)NC43)cc2Cl)cccc1-c1ccccc1

SWS1靶点实验

查看更多实验

实验名称：Drug concentration in heart of C57BL/6 mouse implanted with mouse B16-F10 cells at 50... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352005

实验名称：Drug concentration in liver of C57BL/6 mouse implanted with mouse B16-F10 cells at 50... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352006

实验名称：Antitumor activity against mouse B16-F10 cells implanted in syngeneic C57BL/6 mouse a... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5352003

实验名称：Toxicity in syngeneic C57BL/6 mouse implanted with mouse B16-F10 cells assessed as ef... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352004

实验名称：Antitumor activity against mouse B16-F10 cells implanted in syngeneic C57BL/6 mouse a... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5352001

实验名称：Antitumor activity against mouse B16-F10 cells implanted in syngeneic C57BL/6 mouse a... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5352002

实验名称：Toxicity in BALB/c mouse xenografted with mouse B16-F10 cells assessed as effect on b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5352000

实验名称：Antitumor activity against mouse B16-F10 cells implanted in BALB/c mouse assessed as ... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5351997

实验名称：Antitumor activity against mouse B16-F10 cells implanted in BALB/c mouse assessed as ... 来源：ChEMBL 靶标：B16-F10 External Id：CHEMBL5351998

实验名称：Initial drug concentration in C57BL/6 mouse at 50 mg/kg, ip measured after 4 hrs by H... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5351995

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