Oxyresveratrol

Modify Date: 2024-01-02 10:19:49

Oxyresveratrol structure	Common Name	Oxyresveratrol
	CAS Number	29700-22-9	Molecular Weight	244.243
	Density	1.5±0.1 g/cm3	Boiling Point	523.8±30.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₂O₄	Melting Point	201ºC
	MSDS	N/A	Flash Point	260.8±19.2 °C

Use of Oxyresveratrol

Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]

Name	4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
Synonym	More Synonyms

Description	Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase Research Areas >> Others Natural Products >> Phenols
References	[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003). [2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002). [3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107.

Description

Related Catalog

Signaling Pathways >> Autophagy >> Autophagy

Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

Research Areas >> Others

Natural Products >> Phenols

References

[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003).

[2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002).

[3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107.

Density	1.5±0.1 g/cm3
Boiling Point	523.8±30.0 °C at 760 mmHg
Melting Point	201ºC
Molecular Formula	C₁₄H₁₂O₄
Molecular Weight	244.243
Flash Point	260.8±19.2 °C
Exact Mass	244.073563
PSA	80.92000
LogP	3.17
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.801

Oxyresveratrol MSDS(Chinese)

Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26

4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol

Puag-haad

2,4,3',5'-Tetrahydroxystilbene

3,4,3',5'-tetrahydroxy-trans-stilbene

OXYLRESVERATROL

trans-oxyresveratrol

2,3',4,5'-Tetrahydroxy-trans-stilbene

(E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol

Oxyresveratrol

1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-

EINECS 300-008-4

2,3',4,5'-Tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,3-benzenediol

trans-2,3',4,5'-tetrahydroxystilbene

4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,3-diol

1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-

1,3-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-

BioBioPha
China
Product Name: Oxyresveratrol
Price: ￥Inquiry/50mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Oxyresveratrol
Price: ￥178.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Oxyresveratrol
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Oxyresveratrol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol,29700-22-9
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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