Oxyresveratrol

Modify Date: 2024-01-02 10:19:49

Oxyresveratrol Structure
Oxyresveratrol structure
 Common Name Oxyresveratrol
CAS Number 29700-22-9 Molecular Weight 244.243
Density 1.5±0.1 g/cm3 Boiling Point 523.8±30.0 °C at 760 mmHg
Molecular Formula C14H12O4 Melting Point 201ºC
MSDS N/A Flash Point 260.8±19.2 °C

 Use of Oxyresveratrol


Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]

 Names

Name 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol
Synonym More Synonyms

 Oxyresveratrol Biological Activity

Description Oxyresveratrol is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. It effectively scavenges H2O2, NO (IC50 = 45.3 μM), and the artificial free radical 2,2-diphenyl-l-picrylhydrazyl (IC50 = 28.9 μM) In vitro: 1)oxyresveratrol exhibited more than 50% inhibition at 100 μM on L-tyrosine oxidation by murine tyrosinase activity.2) oxyresveratrol showed an IC50 value of 52.7 μM on the enzyme activity. 3) oxyresveratrol works through reversible inhibition of tyrosinase activity rather than suppression of the expression and synthesis of the enzyme.[2] In vivo: 1) Oxyresveratrol (10 or 20 mg/kg) significantly reduced the brain infarct volume by approximately 54% and 63%, respectively, when compared to vehicle-treated MCAO rats.2) oxyresveratrol treatment diminished cytochrome c release and decreasedcaspase-3 activation in MCAO rats. [3]
Related Catalog
References

[1]. Lorenz. et al. Oxyresveratrol and resveratrol are potent antioxidants and free radical scavengers: Effect on nitrosative and oxidative stress derived from microglial cells. Nitric Oxide 9(2) 64-76 (2003).

[2]. Kim, Y.M., Yun, J., Lee, C., et al. Oxyresveratrol and hydroxystilbene compounds. Inhbitory effect on tyrosinase and mechanism of action. J Biol Chem277(18) 16340-16344 (2002).

[3]. Shaida A Andrabi et al. Oxyresveratrol (trans-2,3′,4,5′-tetrahydroxystilbene) is neuroprotective and inhibits the apoptotic cell death in transient cerebral ischemia. Brain Res, 2004 Aug 13, 1017(1-2):98-107.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 523.8±30.0 °C at 760 mmHg
Melting Point 201ºC
Molecular Formula C14H12O4
Molecular Weight 244.243
Flash Point 260.8±19.2 °C
Exact Mass 244.073563
PSA 80.92000
LogP 3.17
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.801

 Safety Information

Hazard Codes Xi
Risk Phrases 36
Safety Phrases 26

 Synonyms

4-[(E)-2-(3,5-Dihydroxyphenyl)ethenyl]benzene-1,3-diol
Puag-haad
2,4,3',5'-Tetrahydroxystilbene
3,4,3',5'-tetrahydroxy-trans-stilbene
OXYLRESVERATROL
trans-oxyresveratrol
2,3',4,5'-Tetrahydroxy-trans-stilbene
(E)-4-(3,5-Dihydroxystyryl)benzene-1,3-diol
Oxyresveratrol
1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-, (E)-
EINECS 300-008-4
2,3',4,5'-Tetrahydroxystilbene
4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]-1,3-benzenediol
trans-2,3',4,5'-tetrahydroxystilbene
4-[(E)-2-(3,5-Dihydroxyphenyl)vinyl]benzene-1,3-diol
1,3-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
1,3-Benzenediol, 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]-
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