Altretamine (hydrochloride)

Modify Date: 2024-01-04 18:33:12

Altretamine (hydrochloride) structure	Common Name	Altretamine (hydrochloride)
	CAS Number	2975-00-0	Molecular Weight	246.74000
	Density	N/A	Boiling Point	339.4ºC at 760mmHg
	Molecular Formula	C₉H₁₉ClN₆	Melting Point	N/A
	MSDS	N/A	Flash Point	159.1ºC

Use of Altretamine (hydrochloride)

Altretamine hydrochloride is an alkylating antineoplastic agent.

Name	2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine,hydrochloride
Synonym	More Synonyms

Description	Altretamine hydrochloride is an alkylating antineoplastic agent.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker Research Areas >> Cancer
In Vitro	Altretamine hydrochloride is an antineoplastic agent[1].
In Vivo	Altretamine (100, 133 mg/kg, ip.) in combination with Irofulven, increases the antitumor effect in mice bearing MV522 cells[1].
Animal Admin	Mice[1] Balb/c nu/nu 4 week old female mice weighing 18-22 g, receive s.c. injections of 8-10 million MV522 cells. Altretamine is administered i.p. three times a week for 3 weeks, starting on day 10 after tumor implantation. Tumor size is measured in two perpendicular diameters and tumor weight (TW) estimated according to the formula: w = [(width)2 × length/2]. Altretamine is prepared as stock solutions of 1-10 mg/mL in 40% DMSO/normal saline and diluted with 10% DMSO/normal saline as required[1].
References	[1]. Kelner MJ, et al. Synergy of irofulven in combination with other DNA damaging agents: synergistic interaction with altretamine, alkylating, and platinum-derived agents in the MV522 lung tumor model. Cancer Chemother Pharmacol. 2008 Dec;63(1):19-26.

Altretamine hydrochloride

1,3,5-Triazine-2,4,6-triamine,N,N,N',N',N'',N''-hexamethyl-,monohydrochloride

2-N,2-N,4-N,4-N,6-N,6-N-hexamethyl-1,3,5-triazine-2,4,6-triamine hydrochloride

Hexamethylmelamine HCl

Altretamine (hydrochloride)

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Price: $60/100mg