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302-23-8

302-23-8 structure
302-23-8 structure
  • Name: Hydroxyprogesterone acetate
  • Chemical Name: Progesterone Acetate
  • CAS Number: 302-23-8
  • Molecular Formula: C23H32O4
  • Molecular Weight: 372.498
  • Catalog: API Hormone and endocrine-regulating drugs Birth control pills
  • Create Date: 2018-05-16 08:00:00
  • Modify Date: 2025-08-20 17:04:58
  • 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface[1][2].
Name Progesterone Acetate
Synonyms 17-Acetoxyprogesterone
17α-Acetoxyprogesterone
3,20-Dioxopregn-4-en-17-yl acetate
17a-Hydroxy-progesterone acetate
17ALPHA-ACETOXYPROGESTERONE
Prodox acetate
17α-Hydroxy-4-pregnene-3,20-dione 17-acetate
Chlormadinone acetate impurity G
Pregn-4-ene-3,20-dione, 1-(acetyloxy)-
17-Hydroxypregn-4-ene-3,20-dione acetate
EINECS 206-119-6
17-(Acetyloxy)pregn-4-ene-3,20-dione
Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
Hydroxyprogesterone acetate
Acetoxyprogesterone
Pregn-4-ene-3,20-dione, 17-(acetyloxy)-
ProgesteroneAcetate
3,20-Dioxopregn-4-en-1-yl acetate
17-Hydroxyprogesterone 17α-acetate
4-Pregnen-17α-ol-3,20-dione acetate
MFCD00021156
17-Hydroxyprogesterone acetate
Pregn-4-ene-3,20-dione, 17- (acetyloxy)-
17α-Acetoxy-4-pregnene-3,20-dione
17α-Acetoxy-4-pregnene-3,20-dione
17a-Hydroxyprogesterone Acetate
Description 17α-Hydroxyprogesterone acetate possesses progestational activity. 17α-Hydroxyprogesterone acetate has antiinflammatory effects at the murine maternal-fetal interface[1][2].
Related Catalog
In Vitro 17α-Hydroxyprogesterone (Delalutin) is not androgenic, and that it, like progesterone and certain other sex steroids, does not alter the development of nonreproductive organs[1].
References

[1]. R E Seegmiller, et al. Evaluation of the teratogenic potential of delalutin (17 alpha-hydroxyprogesterone caproate) in mice. Teratology. 1983 Oct;28(2):201-8.

[2]. Amy-Eunice Furcron, et al. Vaginal progesterone, but not 17α-hydroxyprogesterone caproate, has antiinflammatory effects at the murine maternal-fetal interface. Am J Obstet Gynecol. 2015 Dec;213(6):846.e1-846.e19.
Density 1.1±0.1 g/cm3
Boiling Point 494.3±45.0 °C at 760 mmHg
Melting Point 249-250ºC
Molecular Formula C23H32O4
Molecular Weight 372.498
Flash Point 213.5±28.8 °C
Exact Mass 372.230072
PSA 60.44000
LogP 3.41
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.541
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5074000
CHEMICAL NAME :
Pregn-4-ene-3,20-dione, 17-hydroxy-, acetate
CAS REGISTRY NUMBER :
302-23-8
LAST UPDATED :
199206
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C23-H32-O4
MOLECULAR WEIGHT :
372.55
WISWESSER LINE NOTATION :
L E5 B666 OV MUTJ A1 E1 FV1 FOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
72 mg/kg
SEX/DURATION :
male 9 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 100,540,1959
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965 Volume(issue)/page/year: -,150,1965
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
896 mg/kg
SEX/DURATION :
female 32 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
80500 ug/kg
SEX/DURATION :
female 23 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 105,23,1960
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
REFERENCE :
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948- Volume(issue)/page/year: 73,17,1963
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
DOSE :
500 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
REFERENCE :
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 7,341,1966
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
100 ug/kg
SEX/DURATION :
female 5 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08- Volume(issue)/page/year: 142,469,1962
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
40 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961 Volume(issue)/page/year: -,37,1961
Symbol GHS08
GHS08
Signal Word Warning
Hazard Statements H351
Precautionary Statements P280
Hazard Codes Xn: Harmful;
Risk Phrases R40
Safety Phrases 22-24/25-45
RIDADR UN 2811 6
WGK Germany 3
RTECS TU5074000
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