Ingenol

Modify Date: 2024-01-02 07:17:37

Ingenol Structure
Ingenol structure
Common Name Ingenol
CAS Number 30220-46-3 Molecular Weight 348.433
Density 1.3±0.1 g/cm3 Boiling Point 523.8±50.0 °C at 760 mmHg
Molecular Formula C20H28O5 Melting Point 153 °C
MSDS N/A Flash Point 284.7±26.6 °C

 Use of Ingenol


Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.

 Names

Name ingenol
Synonym More Synonyms

 Ingenol Biological Activity

Description Ingenol is a PKC activator, with a Ki of 30 μM, with antitumor activity.
Related Catalog
Target

PKC:30 μM (Ki)

In Vitro Ingenol is a PKC activator, with a Ki of 30 μM. Ingenol induces ornithine decarboxylase activity (1, 3 mM), and causes morphological changes (1 mM) in primary mouse epidermal keratinocytes. Ingenol (125 μM, 250 μM, 500 μM, 1 mM) also inhibits cell-cell communication[1].
References

[1]. Hasler CM, et al. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan 1;52(1):202-8.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 523.8±50.0 °C at 760 mmHg
Melting Point 153 °C
Molecular Formula C20H28O5
Molecular Weight 348.433
Flash Point 284.7±26.6 °C
Exact Mass 348.193665
PSA 97.99000
LogP 2.95
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.625

 Safety Information

Hazard Codes Xi: Irritant;
Risk Phrases R38;R41
Safety Phrases 26-36

 Synthetic Route

 Synonyms

(1S,4S,5R,6R,9S,10R,12R,14R)-4,5,6-Trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyltetracyclo[7.5.1.0.0]pentadeca-2,7-dien-15-one
1aa,2a,5b,5ab,6b,8ab,9a,10,10aa-Octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-1a,2,5,5a,6,9,10,10a-Octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1H-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
ingenol
MFCD00056380
1alpha,2,5,5alpha,6,9,10,10alpha-Octahydro-5,5alpha,6-trihydroxy-4-hydroxymethyl-1,1,7,9,-retramethyl-1H-2,8alpha-m
1A,2,5,5A,6,9,10,10A OCTAHYDRO-5,5A,6-TRIHYDROXY4(HYDROXYMETHYL)1,1,7,9-TETRAMETHYL1H-2,8 AMETHANOCYCLOPENTA[A]CYCLOPROPA[E]CYCLODECEN-11 ONE
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