Didemethylclomipramine
Didemethylclomipramine structure
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Common Name | Didemethylclomipramine | ||
|---|---|---|---|---|
| CAS Number | 303-48-0 | Molecular Weight | 337.28700 | |
| Density | 1.129g/cm3 | Boiling Point | 439.5ºC at 760mmHg | |
| Molecular Formula | C18H22Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 219.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of DidemethylclomipramineDidemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine. |
Summary: Didemethylclomipramine (n-desmethylclomipramine hydrochloride,通用英文名：Didemethylclomipramine)，CAS number: 303-48-0，molecular formula: C18H22Cl2N2，molecular weight: 337.29，appears as a powder，boiling point: 439.5ºC，density: 1.129g/cm3. For research-use only, not for medical or clinical usage.
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | n-desmethylclomipramine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.129g/cm3 |
|---|---|
| Boiling Point | 439.5ºC at 760mmHg |
| Molecular Formula | C18H22Cl2N2 |
| Molecular Weight | 337.28700 |
| Flash Point | 219.6ºC |
| Exact Mass | 336.11600 |
| PSA | 15.27000 |
| LogP | 5.44410 |
| Index of Refraction | 1.583 |
| InChIKey | VPIXQGUBUKFLRF-UHFFFAOYSA-N |
| SMILES | CNCCCN1c2ccccc2CCc2ccc(Cl)cc21 |
This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Didemethylclomi... CAS#:303-48-0 |
| Literature: Chaudhuri, Naba K.; Servando, Ofelia; Markus, Bohdan; Galynker, Igor; Sung, Ming-Sang Journal of the Indian Chemical Society, 1985 , vol. 62, # 11 p. 899 - 903 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
|---|---|
| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000) Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami... |
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Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.
J. Affect. Disord. 29(4) , 267-79, (1993) We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D... |
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Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.
Am. J. Vet. Res. 61(1) , 80-5, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages.... |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Demethylchlorimipramine |
| [3-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine |
| N-Desmethylclomipramine HCl |
| Norclomipramine |
| n-desmethylclomipramine |
| Chlordesipramine |
| desmethylclomipramine |
| N-Demethylclomipramine |
| N-Desmethylchlomipramine |
| Desmethylchlomipramine |
| Demethylchlomipramine |
| Desmethylchlorimipramine |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular formula of n-desmethylclomipramine hydrochloride? |
| A: Molecular formula of n-desmethylclomipramine hydrochloride is C18H22Cl2N2. |
| Q: What is the English name of n-desmethylclomipramine hydrochloride? |
| A: The English name of n-desmethylclomipramine hydrochloride is n-desmethylclomipramine hydrochloride. |
| Q: What are the upstream materials of n-desmethylclomipramine hydrochloride? |
| A: Related upstream materials(CAS) of n-desmethylclomipramine hydrochloride: 303-49-1. |
| Q: What is the safety information for n-desmethylclomipramine hydrochloride? |
| A: Safety information for n-desmethylclomipramine hydrochloride: 36. |
| Q: What is the polar surface area (PSA) of n-desmethylclomipramine hydrochloride? |
| A: Polar surface area (PSA) of n-desmethylclomipramine hydrochloride is 15.27000. |
| Q: What is the LogP of n-desmethylclomipramine hydrochloride? |
| A: LogP of n-desmethylclomipramine hydrochloride is 5.44410. |
| Q: What are the uses of n-desmethylclomipramine hydrochloride? |
| A: Main uses of n-desmethylclomipramine hydrochloride: Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine. |
| Q: What is the CAS number of n-desmethylclomipramine hydrochloride? |
| A: CAS number of n-desmethylclomipramine hydrochloride is 303-48-0. |
| Q: What is the InChIKey of n-desmethylclomipramine hydrochloride? |
| A: InChIKey of n-desmethylclomipramine hydrochloride is VPIXQGUBUKFLRF-UHFFFAOYSA-N. |
| Q: What is the molecular weight of n-desmethylclomipramine hydrochloride? |
| A: Molecular weight of n-desmethylclomipramine hydrochloride is 337.28700. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |