去甲氯米帕明 盐酸盐结构式
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常用名 | 去甲氯米帕明 盐酸盐 | 英文名 | Didemethylclomipramine |
|---|---|---|---|---|
| CAS号 | 303-48-0 | 分子量 | 337.28700 | |
| 密度 | 1.129g/cm3 | 沸点 | 439.5ºC at 760mmHg | |
| 分子式 | C18H22Cl2N2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 219.6ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
去甲氯米帕明 盐酸盐用途
本网站展示的所有产品仅用作科学研究，不可食用，不可用于人体或动物的临床诊断和治疗。
Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine. |
| 中文名 | 去甲氯米帕明 盐酸盐 |
|---|---|
| 英文名 | n-desmethylclomipramine hydrochloride |
| 中文别名 | N-去甲氯丙咪嗪 |
| 英文别名 | 更多 |
| 密度 | 1.129g/cm3 |
|---|---|
| 沸点 | 439.5ºC at 760mmHg |
| 分子式 | C18H22Cl2N2 |
| 分子量 | 337.28700 |
| 闪点 | 219.6ºC |
| 精确质量 | 336.11600 |
| PSA | 15.27000 |
| LogP | 5.44410 |
| 外观性状 | 粉末 |
| 折射率 | 1.583 |
| 储存条件 | 室温 |
| 符号 |
GHS07 |
|---|---|
| 信号词 | Warning |
| 危害声明 | H302-H312-H332 |
| 警示性声明 | P280 |
| 个人防护装备 | dust mask type N95 (US);Eyeshields;Gloves |
| 危害码 (欧洲) | Xn: Harmful; |
| 风险声明 (欧洲) | 20/21/22 |
| 安全声明 (欧洲) | 36 |
| 危险品运输编码 | NONH for all modes of transport |
| 海关编码 | 2933990090 |
| 去甲氯米帕明 盐酸盐上游产品 1 | |
|---|---|
| 去甲氯米帕明 盐酸盐下游产品 0 | |
| 海关编码 | 2933990090 |
|---|---|
| 中文概述 | 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0% |
| 申报要素 | 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期 |
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000) Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami... |
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Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.
J. Affect. Disord. 29(4) , 267-79, (1993) We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D... |
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Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.
Am. J. Vet. Res. 61(1) , 80-5, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages.... |
| Demethylchlorimipramine |
| [3-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine |
| N-Desmethylclomipramine HCl |
| Norclomipramine |
| n-desmethylclomipramine |
| Chlordesipramine |
| desmethylclomipramine |
| N-Demethylclomipramine |
| N-Desmethylchlomipramine |
| Desmethylchlomipramine |
| Demethylchlomipramine |
| Desmethylchlorimipramine |
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