Corydalmine

Modify Date: 2024-01-07 13:05:51

Corydalmine structure	Common Name	Corydalmine
	CAS Number	30413-84-4	Molecular Weight	341.401
	Density	1.3±0.1 g/cm3	Boiling Point	501.2±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₂₃NO₄	Melting Point	177-178℃
	MSDS	N/A	Flash Point	256.9±30.1 °C

Use of Corydalmine

Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

Name	(13aS)-2,3,9-Trimethoxy-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2 -a]isoquinolin-10-ol
Synonym	More Synonyms

Description	Corydalmine (L-Corydalmine), an alkaloid isolated from roots of Corydalis Chaerophylla, inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Neurological Disease
Target	CXCR2
In Vivo	Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2].
References	[1]. S Ameer Basha, et al. Effect of 1-corydalmine, an Alkaloid Isolated From Corydalis Chaerophylla Roots on Spore Germination of Some Fungi. Mycobiology. 2007 Jun;35(2):69-71. [2]. Xiange Tang, et al. In Vitro Metabolism of L-Corydalmine, a Potent Analgesic Drug, in Human, Cynomolgus Monkey, Beagle Dog, Rat and Mouse Liver Microsomes. J Pharm Biomed Anal. 2016 Sep 5;128:98-105. [3]. Lin Zhou, et al. Levo-corydalmine Alleviates Vincristine-Induced Neuropathic Pain in Mice by Inhibiting an NF-kappa B-dependent CXCL1/CXCR2 Signaling Pathway. Neuropharmacology. 2018 Jun;135:34-47.

Density	1.3±0.1 g/cm3
Boiling Point	501.2±50.0 °C at 760 mmHg
Melting Point	177-178℃
Molecular Formula	C₂₀H₂₃NO₄
Molecular Weight	341.401
Flash Point	256.9±30.1 °C
Exact Mass	341.162720
PSA	51.16000
LogP	2.93
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.640