Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Doxofylline
Price: ￥198.0/250mg ￥348.0/25g ￥108.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Doxofylline
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Doxofylline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Doxofylline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

69975-86-6

69975-86-6 structure

69975-86-6 structure

Name: Doxofylline
Chemical Name: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
CAS Number: 69975-86-6
Molecular Formula: C₁₁H₁₄N₄O₄
Molecular Weight: 266.253
Catalog: API Respiratory medication Asthma
Create Date: 2018-08-22 12:21:15
Modify Date: 2024-01-02 23:33:03
Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

Name	7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Synonyms	Maxivent Doxofilina [INN-Spanish] Doxofylline 1H-Purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl- Ansimar 7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Ventax Doxofyllinum [INN-Latin] 7-(1,3-dioxolan-2-ylmethyl)theophylline doxophylline EINECS 274-239-6 ABC 12/3 Dioxyfilline 2-(7'-theophyllinemethyl)-1,3-dioxolane 7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione 7-(1,3-dioxolan-2-yl-methyl)3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione MFCD00865218

Description	Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	Adenosine A1 receptor, phosphodiesterase IV[1]
References	[1]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

Density	1.6±0.1 g/cm3
Boiling Point	505.2±53.0 °C at 760 mmHg
Melting Point	144-146ºC
Molecular Formula	C₁₁H₁₄N₄O₄
Molecular Weight	266.253
Flash Point	259.3±30.9 °C
Exact Mass	266.101501
PSA	80.28000
LogP	-0.70
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.700
Water Solubility	Soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5135000

CHEMICAL NAME :: Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-

CAS REGISTRY NUMBER :: 69975-86-6

BEILSTEIN REFERENCE NO. :: 0561195

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H14-N4-O4

MOLECULAR WEIGHT :: 266.29

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ F1 H1 B1- BT5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 965 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4868186

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 426 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 841 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 396 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 216 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport