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69975-86-6

69975-86-6 structure
69975-86-6 structure
  • Name: Doxofylline
  • Chemical Name: 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
  • CAS Number: 69975-86-6
  • Molecular Formula: C11H14N4O4
  • Molecular Weight: 266.253
  • Catalog: API Respiratory medication Asthma
  • Create Date: 2018-08-22 12:21:15
  • Modify Date: 2025-08-21 04:41:23
  • Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.
Name 7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Synonyms Maxivent
Doxofilina [INN-Spanish]
Doxofylline
1H-Purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-
Ansimar
7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
Ventax
Doxofyllinum [INN-Latin]
7-(1,3-dioxolan-2-ylmethyl)theophylline
doxophylline
EINECS 274-239-6
ABC 12/3
Dioxyfilline
2-(7'-theophyllinemethyl)-1,3-dioxolane
7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
7-(1,3-dioxolan-2-yl-methyl)3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
MFCD00865218
Density 1.6±0.1 g/cm3
Boiling Point 505.2±53.0 °C at 760 mmHg
Melting Point 144-146ºC
Molecular Formula C11H14N4O4
Molecular Weight 266.253
Flash Point 259.3±30.9 °C
Exact Mass 266.101501
PSA 80.28000
LogP -0.70
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.700
Water Solubility Soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XH5135000
CHEMICAL NAME :
Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-
CAS REGISTRY NUMBER :
69975-86-6
BEILSTEIN REFERENCE NO. :
0561195
LAST UPDATED :
199806
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H14-N4-O4
MOLECULAR WEIGHT :
266.29
WISWESSER LINE NOTATION :
T56 BN DN FNVNVJ F1 H1 B1- BT5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
965 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4868186
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
426 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
315 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
841 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
396 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
216 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Precautionary Statements P301 + P312 + P330
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36/37
RIDADR NONH for all modes of transport
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