TCS 2314

Modify Date: 2024-01-12 19:33:23

TCS 2314 Structure
TCS 2314 structure
Common Name TCS 2314
CAS Number 317353-73-4 Molecular Weight 522.59
Density N/A Boiling Point N/A
Molecular Formula C28H34N4O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TCS 2314


TCS 2314 is a very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].

 Names

Name [1-({(3S)-4-[(4-{[(2-Methylphenyl)carbamoyl]amino}phenyl)acetyl]- 3-morpholinyl}carbonyl)-4-piperidinyl]acetic acid
Synonym More Synonyms

 TCS 2314 Biological Activity

Description TCS 2314 is a very late antigen-4 (VLA-4, α4β1, CD49d/CD29) antagonist with an IC50 of 4.4 nM[1].
Related Catalog
Target

IC50: 4.4 nM (Very late antigen-4)[1]

References

[1]. Muro F, et al. Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J Med Chem. 2009 Dec 24;52(24):7974-92.

 Chemical & Physical Properties

Molecular Formula C28H34N4O6
Molecular Weight 522.59
Exact Mass 522.24800
PSA 131.77000
LogP 3.08460

 Synonyms

BX 513 hydrochloride
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