Nicotinic acid mononucleotide

Modify Date: 2024-04-05 23:40:57

Nicotinic acid mononucleotide Structure
Nicotinic acid mononucleotide structure
Common Name Nicotinic acid mononucleotide
CAS Number 321-02-8 Molecular Weight 336.21200
Density N/A Boiling Point N/A
Molecular Formula C11H14NO9P Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of Nicotinic acid mononucleotide


Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase[1][2].

 Names

Name 3-Carboxy-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium
Synonym More Synonyms

 Nicotinic acid mononucleotide Biological Activity

Description Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD+. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase[1][2].
Related Catalog
References

[1]. O'Hara JK, et al. Targeting NAD+ metabolism in the human malaria parasite Plasmodium falciparum. PLoS One. 2014 Apr 18;9(4):e94061.

[2]. Khan JA, et al. Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery. Expert Opin Ther Targets. 2007 May;11(5):695-705.

 Chemical & Physical Properties

Molecular Formula C11H14NO9P
Molecular Weight 336.21200
Exact Mass 336.04800
PSA 167.44000
Storage condition 20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Precursor & DownStream

Precursor  2

DownStream  0

 Articles29

More Articles
ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.

Mol. Microbiol. 81(4) , 952-67, (2011)

In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not fo...

Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.

Biochim. Biophys. Acta 1840(1) , 464-75, (2014)

Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucle...

Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.

Biochimie 94(2) , 300-9, (2012)

Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesi...

 Synonyms

3-Carboxy-1-methylpyridiniumiodid
Pyridinium,3-carboxy-1-methyl-,iodide
Trigonelline hydriodide
trigonelline hydroiodide
nicotinic acid mononucleotide
Nicotinsaeure-iodmethylat
Nicotinsaeure-mononucleotid
nicotinic acid methiodide
nicotinate adenine mononucleotide
3-Carboxy-1-methyl-pyridinium,Jodid
3-carboxy-1-methyl-pyridinium,iodide