Nicotinic acid mononucleotide
Nicotinic acid mononucleotide structure
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Common Name | Nicotinic acid mononucleotide | ||
|---|---|---|---|---|
| CAS Number | 321-02-8 | Molecular Weight | 336.21200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H14NO9P | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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ArsAB, a novel enzyme from Sporomusa ovata activates phenolic bases for adenosylcobamide biosynthesis.
Mol. Microbiol. 81(4) , 952-67, (2011) In the homoacetogenic bacterium Sporomusa ovata, phenol and p-cresol are converted into α-ribotides, which are incorporated into biologically active cobamides (Cbas) whose lower ligand bases do not form axial co-ordination bonds with the cobalt ion of the cor... |
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Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica.
Biochim. Biophys. Acta 1840(1) , 464-75, (2014) Cobamide diversity arises from the nature of the nucleotide base. Nicotinate mononucleotide (NaMN):base phosphoribosyltransferases (CobT) synthesize α-linked riboside monophosphates from diverse nucleotide base substrates (e.g., benzimidazoles, purines, pheno... |
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Characterization of human nicotinate phosphoribosyltransferase: Kinetic studies, structure prediction and functional analysis by site-directed mutagenesis.
Biochimie 94(2) , 300-9, (2012) Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesis of NAD(+). Even though NaPRT activity has been described ... |
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NAMPT/PBEF1 enzymatic activity is indispensable for myeloma cell growth and osteoclast activity.
Exp. Hematol. 41(6) , 547-557.e2, (2013) Multiple myeloma (MM) cells typically grow in focal lesions, stimulating osteoclasts that destroy bone and support MM. Osteoclasts and MM cells are hypermetabolic. The coenzyme nicotinamide adenine dinucleotide (NAD(+)) is not only essential for cellular meta... |
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Functional analysis of the nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase (CobT) enzyme, involved in the late steps of coenzyme B12 biosynthesis in Salmonella enterica.
J. Bacteriol. 192(1) , 145-54, (2010) In Salmonella enterica, the CobT enzyme activates the lower ligand base during the assembly of the nucleotide loop of adenosylcobalamin (AdoCbl) and other cobamides. Previously, mutational analysis identified a class of alleles (class M) that failed to restor... |
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Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase from porcine kidney in complex with nicotinate mononucleotide.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 68(Pt 12) , 1488-90, (2012) Quinolinate phosphoribosyltransferase (QAPRTase) is a key enzyme in NAD biosynthesis; it catalyzes the formation of nicotinate mononucleotide (NAMN) from quinolinate and 5-phosphoribosyl-1-pyrophosphate. In order to elucidate the mechanism of NAMN biosynthesi... |
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Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.
PLoS ONE 9(6) , e100062, (2014) Quinolinic acid phosphoribosyltransferase (QAPRTase, EC 2.4.2.19) is a key enzyme in the de novo pathway of nicotinamide adenine dinucleotide (NAD) biosynthesis and a target for the development of new anti-tuberculosis drugs. QAPRTase catalyzes the synthesis ... |
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Involvement of quinolinate phosphoribosyl transferase in promotion of potato growth by a Burkholderia strain.
Appl. Environ. Microbiol. 72(1) , 760-8, (2006) Burkholderia sp. strain PsJN stimulates root growth of potato explants compared to uninoculated controls under gnotobiotic conditions. In order to determine the mechanism by which this growth stimulation occurs, we used Tn5 mutagenesis to produce a mutant, H4... |
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Comparative genomics of NAD biosynthesis in cyanobacteria.
J. Bacteriol. 188(8) , 3012-23, (2006) Biosynthesis of NAD(P) cofactors is of special importance for cyanobacteria due to their role in photosynthesis and respiration. Despite significant progress in understanding NAD(P) biosynthetic machinery in some model organisms, relatively little is known ab... |
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Crystallization and preliminary X-ray crystallographic analysis of quinolinate phosphoribosyltransferase of Helicobacter pylori.
Acta Crystallogr. D Biol. Crystallogr. 59(Pt 7) , 1265-6, (2003) Quinolinic acid phosphoribosyltransferase (NadC; EC 2.4.2.19) is the key enzyme of NAD(+) biosynthesis in both prokaryotes and eukaryotes. NadC catalyzes the decarboxylation of quinolinic acid (QA) to produce nicotinic acid mononucleotide (NAMN), an intermedi... |