SANT-2

Modify Date: 2025-09-13 07:04:39

SANT-2 Structure
SANT-2 structure
Common Name SANT-2
CAS Number 329196-48-7 Molecular Weight 479.95500
Density N/A Boiling Point N/A
Molecular Formula C26H26ClN3O4 Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of SANT-2


SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1].

 Names

Name N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Synonym More Synonyms

 SANT-2 Biological Activity

Description SANT 2 is a potent antagonist of Hh-signaling pathway. Hedgehog (Hh) signaling plays an important role in cell signaling of embryonic development and adult tissue homeostasis. SANT 2 has the potential for the research of several malignancies including Gorlin syndrome (a disorder predisposing to basal cell carcinoma, medulloblastoma and rhabdomyosarcoma), prostate, pancreatic and breast cancers[1].
Related Catalog
References

[1]. Büttner A, et al. Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway. Bioorg Med Chem. 2009 Jul 15;17(14):4943-54.

 Chemical & Physical Properties

Molecular Formula C26H26ClN3O4
Molecular Weight 479.95500
Exact Mass 479.16100
PSA 85.47000
LogP 6.40470
InChIKey VQOJFGFKIVFMDH-UHFFFAOYSA-N
SMILES CCOc1cc(C(=O)Nc2ccc(Cl)c(-c3nc4ccccc4[nH]3)c2)cc(OCC)c1OCC
Storage condition 2-8°C

 Safety Information

Hazard Statements H413
RIDADR NONH for all modes of transport

 Synonyms

sant-2
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