Humanin (human) trifluoroacetate salt
Modify Date: 2025-08-22 19:36:40
Humanin (human) trifluoroacetate salt structure
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Common Name | Humanin (human) trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 330936-69-1 | Molecular Weight | 2687.23000 | |
| Density | 1.43±0.1 g/cm3(Predicted) | Boiling Point | N/A | |
| Molecular Formula | C119H204N34O32S2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of Humanin (human) trifluoroacetate saltHumanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2]. |
| Name | Humanin |
|---|---|
| Synonym | More Synonyms |
| Description | Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2]. |
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| Related Catalog | |
| Target |
Bax |
| In Vitro | Humanin (40 nM，罗丹明偶联；30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。 Humanin (100 μM；10 min) 阻断 Bax 与分离线粒体的关联，并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。 Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。 Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。 |
| In Vivo | Humanin (0.375 mg/kg/hr; 静脉注射) 增加 Zucker 糖尿病脂肪 (ZDF) 大鼠对外周胰岛素敏感性[2]。 |
| References |
| Density | 1.43±0.1 g/cm3(Predicted) |
|---|---|
| Molecular Formula | C119H204N34O32S2 |
| Molecular Weight | 2687.23000 |
| Exact Mass | 2685.48000 |
| PSA | 1126.15000 |
| LogP | 4.77230 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
|---|
| 1-24-Protein humanin (human) |
| Protein (human clone 1 humanin sequence homolog) |
| MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-SER-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA |
| MAPRGFSCLLLLTSEIDLPVKRRA |