N1-Cyclohexylpropane-1,3-diamine

Modify Date: 2024-01-02 09:58:38

N1-Cyclohexylpropane-1,3-diamine Structure
N1-Cyclohexylpropane-1,3-diamine structure
Common Name N1-Cyclohexylpropane-1,3-diamine
CAS Number 3312-60-5 Molecular Weight 156.268
Density 0.9±0.1 g/cm3 Boiling Point 238.7±8.0 °C at 760 mmHg
Molecular Formula C9H20N2 Melting Point −17-−15 °C(lit.)
MSDS Chinese USA Flash Point 112.3±22.0 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of N1-Cyclohexylpropane-1,3-diamine


N-(3-Aminopropyl)cyclohexylamine, a cyclohexylamine derivative, acts as a selective and competitive inhibitor of spermidine synthase. N-(3-Aminopropyl)cyclohexylamine can be used for the research of neurological diseases[1].

 Names

Name N'-cyclohexylpropane-1,3-diamine
Synonym More Synonyms

 N1-Cyclohexylpropane-1,3-diamine Biological Activity

Description N-(3-Aminopropyl)cyclohexylamine, a cyclohexylamine derivative, acts as a selective and competitive inhibitor of spermidine synthase. N-(3-Aminopropyl)cyclohexylamine can be used for the research of neurological diseases[1].
Related Catalog
References

[1]. P J Chu, et al.Antagonistic effect of N-(3-Aminopropyl)cyclohexylamine on neurotrophic action of spermine in primary cultured rat hippocampal and cerebellar neurons. Jpn J Pharmacol. 1995 Dec;69(4):311-5.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 238.7±8.0 °C at 760 mmHg
Melting Point −17-−15 °C(lit.)
Molecular Formula C9H20N2
Molecular Weight 156.268
Flash Point 112.3±22.0 °C
Exact Mass 156.162643
PSA 38.05000
LogP 1.27
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.484

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C: Corrosive;
Risk Phrases R34
Safety Phrases S26-S27-S28-S36/37/39-S45
RIDADR UN 2735 8/PG 2
WGK Germany 1
Packaging Group III
Hazard Class 8
HS Code 2921300090

 Synthetic Route

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N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Journal of the American Chemical Society, , vol. 68, p. 1208,1210

~65%

N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Sun, Pu; Weinreb, Steven M.; Shang, Maoyu Journal of Organic Chemistry, 1997 , vol. 62, # 24 p. 8604 - 8606

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N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Chemische Berichte, , vol. 98, p. 3377 - 3384

~%

N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Chemische Berichte, , vol. 98, p. 3377 - 3384

~%

N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Journal of Organic Chemistry, , vol. 15, p. 51

~%

N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Journal of the American Chemical Society, , vol. 68, p. 1208,1210

~%

N1-Cyclohexylpropane-1,3-diamine Structure

N1-Cyclohexylpr...

CAS#:3312-60-5

Literature: Chemical and Pharmaceutical Bulletin, , vol. 15, p. 228 - 232

 Customs

HS Code 2921300090
Summary 2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles8

More Articles
Effects of inhibitors of spermidine synthase and spermine synthase on polyamine synthesis in rat tissues.

Biochem. Pharmacol. 45(9) , 1897-903, (1993)

Several inhibitors of aminopropyltransferases, developed recently in this laboratory, were tested for their specificity by measuring their effects on six enzyme activities related to polyamine biosynt...

Specific depletion of spermidine and spermine in HTC cells treated with inhibitors of aminopropyltransferases.

J. Biochem. 117(2) , 339-45, (1995)

The effects of a potent spermidine synthase inhibitor, trans-4-methylcyclohexylamine (4MCHA), and a spermine synthase inhibitor, N-(3-aminopropyl)cyclohexylamine (APCHA), on polyamine biosynthesis and...

Inhibition of cell growth by combination of alpha-difluoromethylornithine and an inhibitor of spermine synthase.

J. Biochem. 117(4) , 824-9, (1995)

The inhibitory effect on cell growth of a combination of alpha-difluoromethylornithine (DFMO) and an inhibitor of aminopropyl transferase was examined. N-(3-aminopropyl)cyclohexylamine (APCHA) and tra...

 Synonyms

N1-Cyclohexylpropane-1,3-diamine
MFCD00003838
N-Cyclohexylpropane-1,3-diamine
EINECS 222-001-7
3-amino-1-cyclohexylaminopropane
N-Cyclohexyl-1,3-diaminopropane
1-(Cyclohexylamino)-3-aminopropane
N-Cyclohexyltrimethylendiamin
3-(Aminopropyl)cyclohexylamine
3-(Cyclohexylamino)-1-propylamine
1,3-Propanediamine, N-cyclohexyl-
3-Cyclohexylaminopropylamine
N-Cyclohexyl-1,3-propanediamine
Cyclohexylamine, N-(3-aminopropyl)-
N-(3-Aminopropyl)cyclohexylamine
N-Cyclohexylpropylene 1,3-diamine
3-Cyclohexylamino-1-propylamine
Cyclohexyl-1,3-propanediamine
N-Cyclohexyl-1,3-propylenediamine
3-Cyclohexylaminopropylamin
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