5-Oxopyrrolidine-2-carboxylic acid

Modify Date: 2024-01-02 06:14:50

5-Oxopyrrolidine-2-carboxylic acid Structure
5-Oxopyrrolidine-2-carboxylic acid structure
 Common Name 5-Oxopyrrolidine-2-carboxylic acid
CAS Number 149-87-1 Molecular Weight 129.114
Density 1.4±0.1 g/cm3 Boiling Point 453.1±38.0 °C at 760 mmHg
Molecular Formula C5H7NO3 Melting Point 180-185ºC
MSDS Chinese USA Flash Point 227.8±26.8 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 5-Oxopyrrolidine-2-carboxylic acid


DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].

 Names

Name 5-oxoproline
Synonym More Synonyms

 5-Oxopyrrolidine-2-carboxylic acid Biological Activity

Description DL-Pyroglutamic acid (CAE) as an inactivator of hepatitis B surface, inactivates vaccinia virus, herpes simplex virus, and influenza virus except poliovirus. DL-Pyroglutamic acid is also a possible inhibitor of GABA transaminase, increases GABA amount with antiepileptic action[1][2].
Related Catalog
In Vitro DL-Pyroglutamic acid results 50 and 100% inactivation of the antigen of 0.01-0.025% and 0.025-0.05%, respectively[1]. DL-Pyroglutamic acid is a possible glutamate antagonist, blocks glutamate miniature-end-plate potential in locust muscle-Druce and Bradford[2].
In Vivo DL-Pyroglutamic acid (0.775 mM/L) completely abolishes the myoclonic jerks and EEG spikes in rats model of epileptic by cobalt implantation in the sensorimotor cerebral cortex[2].
References

[1]. Sugimoto Y, et al. N-alpha-Cocoyl-L-arginine ethyl ester, DL-pyroglutamic acid salt, as an inactivator of hepatitis B surface antigen. Antimicrob Agents Chemother. 1979 Sep;16(3):329-32.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 453.1±38.0 °C at 760 mmHg
Melting Point 180-185ºC
Molecular Formula C5H7NO3
Molecular Weight 129.114
Flash Point 227.8±26.8 °C
Exact Mass 129.042587
PSA 66.40000
LogP -2.39
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.512
Water Solubility 5.67 g/100 mL (20 ºC)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29337900

 Synthetic Route

 Customs

HS Code 2933790090
Summary 2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

 Articles1

More Articles
Comparison of capillary electrophoresis-mass spectrometry and hydrophilic interaction chromatography-mass spectrometry for anionic metabolic profiling of urine.

Talanta 132 , 1-7, (2014)

In order to assess the utility of a recently developed capillary electrophoresis-mass spectrometry (CE-MS) method for the study of anionic metabolites in urine, a comparison was made with hydrophilic ...

 Synonyms

MFCD00064322
L-Pidolic acid
H-DL-Pyr-OH
DL-2-Pyrrolidone-5-carboxylic acid
(S)-(-)-2-pyrrolidone-5-carboxylic acid
Ajidew A 100
Pyrrolidonecarboxylic acid
(S)-(-)-γ-Butyrolactam-γ-carboxylic acid
PyroGlu
L-Proline, 5-oxo-
5-Oxopyrrolidine-2-carboxylic Acid
Pyroglutamic acid
2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-5-hydroxy-, (2S)-
L-5-Oxoproline
DL-Pyroglutamic acid
(S)-(−)-Pyroglutamic acid
a-Aminoglutaric Acid Lactam
5-oxo-proline
(S)-(−)-2-Pyrrolidone-5-carboxylic acid
(-)-Pyroglutamic acid
L-Glutamic Acid g-Lactam
5-Oxo-L-proline
5-Pyrrolidinone-2-carboxylic acid
D,l-2-Pyrrolidone-5-Carboxylic Acid
Proline, 5-oxo-, L-
PCA
Glutamic Acid Lactam
2-L-Pyrrolidone-5-carboxylic acid
pidolic acid
EINECS 205-748-3
(2S)-5-Hydroxy-3,4-dihydro-2H-pyrrole-2-carboxylic acid
DL-Glutamic Acid Lactam
5-L-oxoproline
2-Pyrrolidone-5-carboxylic acid
(S)-(-)-g-Butyrolactam-g-carboxylic Acid
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