Nexinhib20

Modify Date: 2024-04-08 16:44:29

Nexinhib20 structure	Common Name	Nexinhib20
	CAS Number	331949-35-0	Molecular Weight	300.31
	Density	1.2±0.1 g/cm3	Boiling Point	508.2±60.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₆N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	261.2±32.9 °C

Use of Nexinhib20

Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity[1].

Name	Nexinhib20
Synonym	More Synonyms

Description	Nexinhib20 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Ras
Target	IC50: 2.6 μM (Rab27a-JFC1 interaction)[1]
References	[1]. Jennifer L Johnson, et al. Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem. 2016 Dec 9;291(50):25965-25982. [2]. Johnson JL, et al. Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a. J Biol Chem. 2016 Dec 9;291(50):25965-25982.

Density	1.2±0.1 g/cm3
Boiling Point	508.2±60.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₆N₄O₃
Molecular Weight	300.31
Flash Point	261.2±32.9 °C
Exact Mass	300.122253
LogP	2.50
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.601

(1Z)-4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one

Nexinhib20

4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one

(1Z)-4,4-Dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-penten-3-one

MFCD00219515

1-Penten-3-one, 4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)-, (1Z)-

4,4-dimethyl-1-(3-nitrophenyl)-2-(1H-1,2,4-triazol-1-yl)pent-1-en-3-one

(Z)-4,4-Dimethyl-1-(3-nitro-phenyl)-2-[1,2,4]triazol-1-yl-pent-1-en-3-one

Nexinhib20

Use of Nexinhib20

Names

Nexinhib20 Biological Activity

Chemical & Physical Properties

Synonyms