AZ 10397767
Modify Date: 2024-09-29 19:29:06
AZ 10397767 structure
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Common Name | AZ 10397767 | ||
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| CAS Number | 333742-63-5 | Molecular Weight | 400.879 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H14ClFN4O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZ 10397767AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0; weakly inhibits CXCL8 binding to CXCR1 with pIC50<7, and no affinity for CCR2 and CCR5; significantly attenuates IL-8-induced c-FLIP mRNA up-regulation whereas inhibition of AR- and/or NF-kappaB-mediated transcription attenuated IL-8-induced c-FLIP expression in LNCaP and PC3 cells, respectively; attenuates oxaliplatin-induced NF-kappaB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. |
| Name | 5-[(3-Chloro-2-fluorobenzyl)sulfanyl]-7-{[(2R)-1-hydroxy-2-propanyl]amino}[1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one |
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| Synonym | More Synonyms |
| Description | AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0; weakly inhibits CXCL8 binding to CXCR1 with pIC50<7, and no affinity for CCR2 and CCR5; significantly attenuates IL-8-induced c-FLIP mRNA up-regulation whereas inhibition of AR- and/or NF-kappaB-mediated transcription attenuated IL-8-induced c-FLIP expression in LNCaP and PC3 cells, respectively; attenuates oxaliplatin-induced NF-kappaB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. |
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| References | References 1. Wilson C, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):746-59. 2. Seaton A, et al. Carcinogenesis. 2008 Jun;29(6):1148-56. 3. Wilson C, et al. Mol Cancer Ther. 2008 Sep;7(9):2649-61. 4. Walters I, et la. Bioorg Med Chem Lett. 2008 Jan 15;18(2):798-803. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.6±0.1 g/cm3 |
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| Molecular Formula | C15H14ClFN4O2S2 |
| Molecular Weight | 400.879 |
| Exact Mass | 400.023071 |
| LogP | 5.03 |
| Index of Refraction | 1.708 |
| 5-[(3-chloro-2-fluorobenzyl)sulfanyl]-7-{[(2R)-1-hydroxypropan-2-yl]amino}[1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one |
| Thiazolo[4,5-d]pyrimidin-2(3H)-one, 5-[[(3-chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]- |
| 5-[(3-Chloro-2-fluorobenzyl)sulfanyl]-7-{[(2R)-1-hydroxy-2-propanyl]amino}[1,3]thiazolo[4,5-d]pyrimidin-2(3H)-one |