LUF 5834

Modify Date: 2024-01-12 12:07:28

LUF 5834 structure	Common Name	LUF 5834
	CAS Number	333962-91-7	Molecular Weight	348.38
	Density	1.5±0.1 g/cm3	Boiling Point	655.8±65.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₂N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	350.4±34.3 °C

Use of LUF 5834

LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM). LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].

Name	LUF5834
Synonym	More Synonyms

Description	LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM). LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2BR:12 nM (EC50) A2AR:28 nM (Ki) A1R:2.6 nM (Ki)
References	[1]. Beukers MW, et al. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem. 2004 Jul 15;47(15):3707-9. [2]. Lane JR, et al. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptor. Mol Pharmacol. 2012 Mar;81(3):475-87.

Density	1.5±0.1 g/cm3
Boiling Point	655.8±65.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₂N₆OS
Molecular Weight	348.38
Flash Point	350.4±34.3 °C
Exact Mass	348.079315
LogP	2.75
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.753

2-Amino-4-(4-hydroxyphenyl)-6-[(2H-imidazol-2-ylmethyl)sulfanyl]-3,5-pyridinedicarbonitrile

3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-[(2H-imidazol-2-ylmethyl)thio]-

LUF5834

2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile

LUF 5834

Use of LUF 5834

Names

LUF 5834 Biological Activity

Chemical & Physical Properties

Synonyms