333962-91-7

333962-91-7 structure

Name: LUF 5834
Chemical Name: LUF5834
CAS Number: 333962-91-7
Molecular Formula: C₁₇H₁₂N₆OS
Molecular Weight: 348.38
Create Date: 2021-01-07 13:17:33
Modify Date: 2024-01-12 12:07:28
LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM). LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].

Name	LUF5834
Synonyms	2-Amino-4-(4-hydroxyphenyl)-6-[(2H-imidazol-2-ylmethyl)sulfanyl]-3,5-pyridinedicarbonitrile 3,5-Pyridinedicarbonitrile, 2-amino-4-(4-hydroxyphenyl)-6-[(2H-imidazol-2-ylmethyl)thio]- LUF5834 2-amino-4-(4-hydroxyphenyl)-6-(1H-imidazol-2-ylmethylsulfanyl)pyridine-3,5-dicarbonitrile

Description	LUF5834 is a selective A2B adenosine receptor (A2BR) partial agonist (EC50 = 12 nM). LUF5834 is also a partial A1/A2A adenosine receptor agonist (lacking selectivity) with Ki values of 2.6 and 28 nM, respectively[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	A2BR:12 nM (EC50) A2AR:28 nM (Ki) A1R:2.6 nM (Ki)
References	[1]. Beukers MW, et al. New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem. 2004 Jul 15;47(15):3707-9. [2]. Lane JR, et al. A novel nonribose agonist, LUF5834, engages residues that are distinct from those of adenosine-like ligands to activate the adenosine A(2a) receptor. Mol Pharmacol. 2012 Mar;81(3):475-87.