iMAC2

Modify Date: 2026-07-16 19:33:04

iMAC2 structure	Common Name	iMAC2
	CAS Number	335166-36-4	Molecular Weight	469.19
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₀Br₂FN₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of iMAC2

iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release[1].

Name	3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dih ydrochloride

Description	iMAC2 is a potent MAC inhibitor with an IC50 of 28 nM and an LD50 of 15000 nM. iMAC2 shows anti-apoptotic effect. iMAC2 blocks cytochrome c release[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Others Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 28 nM (MAC)[1]
References	[1]. Peixoto PM, et al. MAC inhibitors suppress mitochondrial apoptosis. Biochem J. 2009 Oct 12;423(3):381-7.

Molecular Formula	C₁₉H₂₀Br₂FN₃
Molecular Weight	469.19
Exact Mass	538.95400
PSA	20.20000
LogP	6.43350
InChIKey	BSTYITXHUQTYBA-UHFFFAOYSA-N
SMILES	FC(CN1CCNCC1)Cn1c2ccc(Br)cc2c2cc(Br)ccc21

Name: NCATS Kinetic Aqueous Solubility Profiling
Source: NCGC
Target: N/A
External Id: ADME-solubility1

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: In vitro inhibition of Bax regulated release of cytochrome C was determined using lip...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL692783

Name: Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A7681

Name: NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling
Source: NCGC
Target: N/A
External Id: ADME-PAMPA1

Name: In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL690114

Name: In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ...
Source: ChEMBL
Target: HeLa
External Id: CHEMBL690113

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iMAC2

Use of iMAC2

Names

iMAC2 Biological Activity

Chemical & Physical Properties

iMAC2Bioassay

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.