iMAC2

• 常用名: iMAC2
• 英文名: iMAC2
• CAS号: 335166-36-4
• 分子量: 469.19
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₂₀Br₂FN₃
• 熔点: N/A
• 闪点: N/A

iMAC2用途

iMAC2是一种有效的MAC抑制剂,IC50为28 nM,LD50为15000 nM。iMAC2具有抗凋亡作用。iMAC2阻断细胞色素c的释放[1]。

iMAC2名称

• 英文名: 3,6-Dibromo-9-[2-fluoro-3-(1-piperazinyl)propyl]-9H-carbazole dih ydrochloride

iMAC2生物活性

• 描述: iMAC2是一种有效的MAC抑制剂,IC50为28 nM,LD50为15000 nM。iMAC2具有抗凋亡作用。iMAC2阻断细胞色素c的释放[1]。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 其他
  信号通路 >> 抗感染 >> 细菌
• 靶点实验:

  IC50: 28 nM (MAC)[1]

• 参考文献:

  [1]. Peixoto PM, et al. MAC inhibitors suppress mitochondrial apoptosis. Biochem J. 2009 Oct 12;423(3):381-7.

iMAC2物理化学性质

• 分子式: C₁₉H₂₀Br₂FN₃
• 分子量: 469.19
• 精确质量: 538.95400
• PSA: 20.20000
• LogP: 6.43350
• InChIKey: BSTYITXHUQTYBA-UHFFFAOYSA-N
• SMILES: FC(CN1CCNCC1)Cn1c2ccc(Br)cc2c2cc(Br)ccc21

iMAC2靶点实验

查看更多实验

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：In vitro inhibition of Bax regulated release of cytochrome C was determined using lip... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL692783

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) Profiling 来源：NCGC 靶标：N/A External Id：ADME-PAMPA1

实验名称：In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL690114

实验名称：In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL690113

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