Predef

Modify Date: 2024-01-09 00:24:26

Predef Structure
Predef structure
 Common Name Predef
CAS Number 338-98-7 Molecular Weight 420.471
Density 1.3±0.1 g/cm3 Boiling Point 576.5±50.0 °C at 760 mmHg
Molecular Formula C23H29FO6 Melting Point 244-246 °C
MSDS N/A Flash Point 302.5±30.1 °C

 Use of Predef


Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2].

 Names

Name Isoflupredone Acetate
Synonym More Synonyms

 Predef Biological Activity

Description Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2].
Related Catalog
In Vitro Isoflupredone acetate (10-4, 10-7, or 10-10 M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7 M and 10-10 M) than the high concentration (10-4 M)[1].
In Vivo Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to faster Mannheimia haemolytica-infected clinical improvement when co-treated with Oxytetracycline (HY-B0275)[2]. Animal Model: 96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion of Mannheimia haemolytica)[2] Dosage: 0.05 mg/kg Administration: i.m.; on days 2 and 4 after the challenge Result: Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers.Prevented these reductions and resulted in faster clinical improvement when co-treated with Oxytetracycline (HY-B0275).

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 576.5±50.0 °C at 760 mmHg
Melting Point 244-246 °C
Molecular Formula C23H29FO6
Molecular Weight 420.471
Flash Point 302.5±30.1 °C
Exact Mass 420.194824
PSA 100.90000
LogP 2.46
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.577
Storage condition -20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3970000
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate
CAS REGISTRY NUMBER :
338-98-7
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H29-F-O6
MOLECULAR WEIGHT :
420.52
WISWESSER LINE NOTATION :
L E5 B666 OV AHTTT&J A1 BF CQ E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
120 ug/kg
SEX/DURATION :
female 38 week(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
REFERENCE :
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915- Volume(issue)/page/year: 160,867,1972

 Safety Information

RIDADR NONH for all modes of transport

 Synthetic Route

Fludrocortisone acetate structure

Fludrocortisone...

CAS#:514-36-3

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Helvetica Chimica Acta, , vol. 39, p. 734,741
(8S,9R,10S,11S,13S,14S,17R)-2'-ethoxy-9-fluoro-11-hydroxy-2',10,13-trimethyl-7,8,9,10,11,12,13,14,15,16-decahydrospiro[cyclopenta[a]phenanthrene-17,4'-[1,3]dioxane]-3,5'(6H)-dione structure

(8S,9R,10S,11S,...

CAS#:40627-86-9

~0%

Predef Structure

Predef

CAS#:338-98-7

9α-Fluor-prednisolon-acetat-(17α) structure

9α-Fluor-predni...

CAS#:3793-90-6

Literature: McLean; Khalil; Heiman; Lee Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 4 p. 476 - 480
9α-Fluor-5α-pregnantriol-(11β,17α,21)-dion-(3,20)-acetat-(21) structure

9α-Fluor-5α-pre...

CAS#:1812-91-5

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of the American Chemical Society, , vol. 77, p. 4181 Journal of the American Chemical Society, , vol. 77, p. 3166 US2848464 , ;
21-acetoxy-9,11β-epoxy-17-hydroxy-9β-pregna-1,4-diene-3,20-dione structure

21-acetoxy-9,11...

CAS#:38680-83-0

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of the American Chemical Society, , vol. 77, p. 4436 Journal of the American Chemical Society, , vol. 77, p. 4181 Journal of the American Chemical Society, , vol. 78, p. 4956,4959
pregna-1,4,9(11)-triene-17α,21-diol-3,20-dione 21-acetate structure

pregna-1,4,9(11...

CAS#:4380-55-6

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of the American Chemical Society, , vol. 77, p. 4181
9α-Brom-11β,17α-dihydroxy-21-acetoxy-pregna-1,4-dien-3,20-dion structure

9α-Brom-11β,17α...

CAS#:4224-31-1

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of the American Chemical Society, , vol. 77, p. 4181
Prednisolone Acetate structure

Prednisolone Acetate

CAS#:52-21-1

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of the American Chemical Society, , vol. 77, p. 4181
9-fluoroprednisolone structure

9-fluoroprednisolone

CAS#:338-95-4

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Journal of Pharmaceutical Sciences, , vol. 83, # 4 p. 476 - 480
9-fluoroprednisolone structure

9-fluoroprednisolone

CAS#:338-95-4

Ethanoic anhydride structure

Ethanoic anhydride

CAS#:108-24-7

~%

Predef Structure

Predef

CAS#:338-98-7

Literature: Helvetica Chimica Acta, , vol. 38, p. 1502,1506

 Synonyms

(11b)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl Acetate
21-Acetoxy-9-fluoro-11β,17-dihydroxypregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI)
(11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregna-1,4-dien-21-yl acetate
[2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
9-Fluoro-11β,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
9-Fluoroprednisolone 21-acetate
Pregna-1,4-diene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate
9α-Fluoro-11β,17α,21-trihydroxypregna-1,4-diene-3,20-dione 21-acetate
Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
Predef
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