Dovramilast
Modify Date: 2024-09-17 06:32:19
Dovramilast structure
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Common Name | Dovramilast | ||
|---|---|---|---|---|
| CAS Number | 340019-69-4 | Molecular Weight | 472.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H28N2O6S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DovramilastDovramilast (CC-11050) is an oral phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast (CC-11050), as an adjunct, is used for the research of tuberculosis (TB)[1]. |
| Name | Dovramilast |
|---|
| Description | Dovramilast (CC-11050) is an oral phosphodiesterase 4 (PDE4) inhibitor and can reduce the inflammatory response and improves Isoniazid (INH)-mediated bacillary clearance from the lungs. Dovramilast (CC-11050), as an adjunct, is used for the research of tuberculosis (TB)[1]. |
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| Related Catalog | |
| Target |
PDE4 |
| In Vivo | Dovramilast (oral gavage, 5, 25, or 50 mg/kg, single) significantly improves antibiotic-mediated bacterial killing and reduces lung pathology[2]. Pharmacokinetic Parameters of Dovramilast in B6D2F1 mice[2]. Sampling time(h) Concentration(ng/ml) CC-11050 only CC-11050+INH 1 1,331.6±136.97 905.35±594.23 2 1,409.47±140.85 1,309.39±214.08 5 948.85±128.7 1,609.18±167.2 8 820.6±265.98 1,271.73±249.18 24 1.27±1.1 4.96±1.85 Tmax(h) 2.0 5.0 Cmax(ng/ml) 1,410 1,610 AUClast(ng × h/ml) 10,200 13,900 Animal Model: B6D2F1 mice[2] Dosage: 5, 25, or 50 mg/kg Administration: oral, 5, 25, or 50 mg/kg, single Result: Reduced PDE4 expression in mtb-infected mouse lungs. Animal Model: B6D2F1 mice[2] Dosage: 5, 25, or 50 mg/kg Administration: oral gavage, 5, 25, or 50 mg/kg, single Result: |
| References |
| Molecular Formula | C24H28N2O6S |
|---|---|
| Molecular Weight | 472.55 |
| InChIKey | QDZOBXFRIVOQBR-LJQANCHMSA-N |
| SMILES | CCOc1cc(C(CS(C)(=O)=O)N2Cc3cccc(NC(=O)C4CC4)c3C2=O)ccc1OC |