TM5007

Modify Date: 2024-01-09 20:18:40

TM5007 Structure
TM5007 structure
Common Name TM5007
CAS Number 342595-05-5 Molecular Weight 560.69
Density 1.5±0.1 g/cm3 Boiling Point 800.4±65.0 °C at 760 mmHg
Molecular Formula C24H20N2O6S4 Melting Point N/A
MSDS N/A Flash Point 437.8±34.3 °C

 Use of TM5007


TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung[1].

 Names

Name 5-({6-[(4'-Carboxy-2,3'-bithiophen-5'-yl)amino]-6-oxohexanoyl}amino)-2,3'-bithiophene-4'-carboxylic acid
Synonym More Synonyms

 TM5007 Biological Activity

Description TM5007 is a poent and orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1) with an IC50 of 29 μM. TM5007 enhance fibrinolysis activity and inhibits coagulation. TM5007 also prevents the fibrotic process initiated by bleomycin in mouse lung[1].
Related Catalog
References

[1]. Izuhara Y, et al. Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis. Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):672-7.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 800.4±65.0 °C at 760 mmHg
Molecular Formula C24H20N2O6S4
Molecular Weight 560.69
Flash Point 437.8±34.3 °C
Exact Mass 560.020386
LogP 4.96
Vapour Pressure 0.0±3.0 mmHg at 25°C
Index of Refraction 1.730

 Synonyms

5-({6-[(4'-Carboxy-2,3'-bithiophen-5'-yl)amino]-6-oxohexanoyl}amino)-2,3'-bithiophene-4'-carboxylic acid
[2,3'-Bithiophene]-4'-carboxylic acid, 5-[[6-[(4'-carboxy[2,3'-bithiophen]-5'-yl)amino]-1,6-dioxohexyl]amino]-