Harmine hydrochloride
Harmine hydrochloride structure
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Common Name | Harmine hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 343-27-1 | Molecular Weight | 248.708 | |
| Density | N/A | Boiling Point | 421.4ºC at 760mmHg | |
| Molecular Formula | C13H13ClN2O | Melting Point | 265-270°C | |
| MSDS | N/A | Flash Point | 139.8ºC | |
Use of Harmine hydrochlorideHarmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. |
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| Related Catalog | |
| Target |
Ki: 397 nM (5-HT2A serotonin receptor)[1], DYRK1A[2] |
| In Vitro | Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC50 of 190 nM[2]. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine[3]. |
| In Vivo | It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group[4]. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 421.4ºC at 760mmHg |
|---|---|
| Melting Point | 265-270°C |
| Molecular Formula | C13H13ClN2O |
| Molecular Weight | 248.708 |
| Flash Point | 139.8ºC |
| Exact Mass | 248.071640 |
| PSA | 37.91000 |
| LogP | 3.83510 |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xn: Harmful; |
|---|---|
| Risk Phrases | R20/21/22 |
| Safety Phrases | S22-S36 |
| RIDADR | 1544 |
| WGK Germany | 3 |
| RTECS | MG9450000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2933990090 |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 7-Methoxy-1-methyl-9H-β-carbolinhydrochlorid |
| 7-Methoxy-1-methyl-9H-β-carboline hydrochloride |
| Harmine.HCL |
| EINECS 206-443-8 |
| Harmine hydrochloride hydrate |
| Harmine monohydrochloride |
| MFCD00012641 |
| 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, monohydrochloride |
| HARMINE HYDROCHLORIDE |
| 7-Methoxy-1-methyl-9H-β-carboline hydrochloride (1:1) |
| 7-Méthoxy-1-méthyl-9H-β-carboline chlorhydrate |
| 9H-Pyrido[3,4-b]indole, 7-methoxy-1-methyl-, hydrochloride (1:1) |
| Banisterine Hydrochloride |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the polar surface area (PSA) of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Polar surface area (PSA) of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 37.91000. |
| Q: What are the uses of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Main uses of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride: Harmine Hydrochloride (Telepathine Hydrochloride) is a natural dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM[1]. |
| Q: What is the molecular weight of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Molecular weight of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 248.708. |
| Q: What is the molecular formula of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Molecular formula of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is C13H13ClN2O. |
| Q: What is the CAS number of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: CAS number of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 343-27-1. |
| Q: What is the English name of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: The English name of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride. |
| Q: What is the LogP of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: LogP of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 3.83510. |
| Q: What is the safety information for 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Safety information for 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride: S22-S36. |
| Q: What is the melting point of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Melting point of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 265-270°C. |
| Q: What is the boiling point of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride? |
| A: Boiling point of 7-methoxy-1-methyl-9H-pyrido[3,4-b]indole,hydrochloride is 421.4ºC at 760mmHg. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| naturewill |