SUN B8155
Modify Date: 2025-08-20 15:02:18
SUN B8155 structure
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Common Name | SUN B8155 | ||
|---|---|---|---|---|
| CAS Number | 345893-91-6 | Molecular Weight | 273.28700 | |
| Density | 1.34g/cm3 | Boiling Point | 419ºC at 760 mmHg | |
| Molecular Formula | C14H15N3O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 207.2ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of SUN B8155SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis[1]. |
| Name | SUN-B 8155,5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridone |
|---|---|
| Synonym | More Synonyms |
| Description | SUN B8155, a non-peptide agonist of calcitonin (CT) receptor, selectively mimics the biological actions of calcitonin. Calcitonin, a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis[1]. |
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| Related Catalog | |
| In Vitro | SUN B8155 (1-1000 μM; 1 hour) stimulates intracellular cAMP formation in T47D cells in a concentration-dependent manner; the concentration of synthesized cAMP increased by approximately 42-fold at the highest concentration. SUN B8155 also stimulates cAMP formation in the rat osteogenic sarcoma-derived cell line, UMR106-06[1]. SUN B8155 does not stimulate cAMP formation in CHO/hPTHR or parental CHO cells, but fully stimulates cAMP formation in CHO/hCTR cells in a concentration-dependent manner with an EC50 of 21 μM[1]. |
| In Vivo | SUN B8155 (100 mg/kg; i.p.) results in a significant reduction of serum calcium concentration by approximately 9% at 30 min after administration. Human CT also reduces serum calcium in a dose-dependent manner at 30 min (0.1 and 0.3 μg/kg) and 60 min (0.3 μg/kg) after administration[1]. |
| References |
| Density | 1.34g/cm3 |
|---|---|
| Boiling Point | 419ºC at 760 mmHg |
| Molecular Formula | C14H15N3O3 |
| Molecular Weight | 273.28700 |
| Flash Point | 207.2ºC |
| Exact Mass | 273.11100 |
| PSA | 100.84000 |
| LogP | 2.40370 |
| Index of Refraction | 1.637 |
| InChIKey | SGJLINMLDNLWOS-UHFFFAOYSA-N |
| SMILES | CC(=Nc1ccccc1N)c1c(C)cc(=O)n(O)c1O |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| RIDADR | UN 2811 6.1 / PGIII |
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Discovery of a non-peptide small molecule that selectively mimics the biological actions of calcitonin.
Biochim. Biophys. Acta 1526 , 183-190, (2001) Calcitonin (CT), a 32-amino acid peptide hormone secreted mainly from the thyroid gland, plays an important role in maintaining bone homeostasis. To discover non-peptide small molecules with biologica... |
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Name: Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro...
Source: NCGC
Target: N/A
External Id: SERCaMPGLuc-p1-antagonist
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Name: Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: HCMV UL50
External Id: HMS1262
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4513082
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Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315
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Name: qHTS for Inhibitors of Polymerase Kappa
Source: NCGC
Target: DNA polymerase kappa [Homo sapiens]
External Id: PolK100
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Name: Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac...
Source: ChEMBL
Target: Severe acute respiratory syndrome coronavirus 2
External Id: CHEMBL4303805
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Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582
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Name: Tocris HTS for Inhibitors of Aerobactin Synthetase lucA
Source: 23265
External Id: IucA Pilot Assay Tocris Library
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Name: Antiviral activity against HBV infected in human HepDES19 cells assessed as inhibitio...
Source: ChEMBL
Target: Hepatitis B virus
External Id: CHEMBL5620890
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Name: Enzymatic assay of human HDAC6 with commercial peptide substrate
Source: ChEMBL
Target: Histone deacetylase 6
External Id: CHEMBL4808149
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| 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridinone |