345989-24-4
345989-24-4 structure
- Name: MIND4-17
- Chemical Name: MIND4-17
- CAS Number: 345989-24-4
- Molecular Formula: C20H15N5O3S
- Molecular Weight: 405.430
- Catalog: Signaling Pathways NF-κB Keap1-Nrf2
- Create Date: 2020-01-12 07:16:50
- Modify Date: 2024-01-16 19:23:53
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An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes.
| Name | MIND4-17 |
|---|---|
| Synonyms |
MIND4-17
5-Nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}pyridine 5-nitro-2-{[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}pyridine Pyridine, 5-nitro-2-[[5-(phenoxymethyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio]- MFCD01899657 |
| Description | An inducer of NRF2 that selectively activates NRF2 signaling with CD value (The concentration that doubles the specific activity) of 0.18 uM; covalently modifies a critical stress-sensor cysteine (C151) of the E3 ligase substrate adaptor protein KEAP1, arrests KEAP/NRF2 complex in the closed conformation in live cells; potently represses the release of the proinflammatory cytokine IL-6 in primary mouse HD and WT microglia and astrocytes. |
|---|---|
| References | References 1. Quinti L, et al. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4676-E4685. View Related Products by Target Keap1-Nrf2 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 667.5±65.0 °C at 760 mmHg |
| Molecular Formula | C20H15N5O3S |
| Molecular Weight | 405.430 |
| Flash Point | 357.5±34.3 °C |
| Exact Mass | 405.089569 |
| LogP | 5.49 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.698 |