HSL-IN-3

Modify Date: 2024-01-21 01:00:56

HSL-IN-3 Structure
HSL-IN-3 structure
Common Name HSL-IN-3
CAS Number 346656-34-6 Molecular Weight 262.109
Density 1.1±0.1 g/cm3 Boiling Point 384.8±25.0 °C at 760 mmHg
Molecular Formula C14H19BO4 Melting Point N/A
MSDS N/A Flash Point 186.5±23.2 °C

 Use of HSL-IN-3


HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL)[1].

 Names

Name ethyl 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate
Synonym More Synonyms

 HSL-IN-3 Biological Activity

Description HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL)[1].
Related Catalog
Target

HSL[1].

References

[1]. Ebdrup, Soren, et al. PHARMACEUTICAL USE OF BORONIC ACIDS AND ESTERS THEREOF. US7037905.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 384.8±25.0 °C at 760 mmHg
Molecular Formula C14H19BO4
Molecular Weight 262.109
Flash Point 186.5±23.2 °C
Exact Mass 262.137634
PSA 44.76000
LogP 1.63150
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.499

 MSDS


Section I.Chemical Product and Company Identification
Chemical Name Ethyl 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoate
Portland OR
SynonymBenzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-,
ethyl ester (CA INDEX NAME);
2-(2-Carbethoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane;
2-(2-Ethoxycarbonylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane;
2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoic Acid
Ethyl Ester
Chemical FormulaC14H19BO4
346656-34-6
CAS Number

Section II.Composition and Information on Ingredients
Chemical NameCAS Number Percent (%)TLV/PELToxicology Data
Ethyl 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 346656-34-6 Min. 98.0 (T) Not available.Not available.

Section III. Hazards Identification
Acute Health EffectsNo specific information is available in our data base regarding the toxic effects of this material for humans. However,
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling
this compound.
Chronic Health EffectsCARCINOGENIC EFFECTS : Not available.
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.

Section IV.First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15
minutes. Get medical attention.
Skin ContactIn case of contact, immediately flush skin with plenty of water. Remove contaminated clothing and shoes. Wash clothing
before reuse. Thoroughly clean shoes before reuse. Get medical attention.
If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
Inhalation
waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
improve.
INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
Ingestion
Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
material was ingested; the absence of such signs, however, is not conclusive.

Section V.Fire and Explosion Data
Not available.
May be combustible at high temperature.Auto-Ignition
Flammability
Flash PointsFlammable LimitsNot available.
Not available.
These products are toxic carbon oxides (CO, CO2). Borates.
Combustion Products
Fire Hazards
Not available.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards
Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media
SMALL FIRE: Use DRY chemical powder.
LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
and Instructions
Consult with local fire authorities before attempting large scale fire-fighting operations.
Continued on Next Page
Ethyl 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

Section VI.Accidental Release Measures
Spill CleanupHeat sensitive material.
Absorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning the spill by rinsing
Instructions
any contaminated surfaces with copious amounts of water. Consult federal, state, and/or local authorities for assistance on
disposal.

Section VII. Handling and Storage
HEAT SENSITIVE. REFRIGERATE.
Handling and Storage
Keep away from heat. Mechanical exhaust required. When not in use, tightly seal the container and store in a dry, cool
Information
place. Avoid excessive heat and light. Do not breathe gas/fumes/ vapor/spray.
Always store away from incompatible compounds such as oxidizing agents.

Section VIII. Exposure Controls/Personal Protection
Provide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective
Engineering Controls
threshold limit value. Ensure that eyewash station and safety shower is proximal to the work-station location.
Splash goggles. Lab coat. Vapor respirator. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
Personal Protection
specialist BEFORE handling this product. Be sure to use a MSHA/NIOSH approved respirator or equivalent.
Exposure LimitsNot available.

Section IX. Physical and Chemical Properties
Liquid. (Clear. Pale yellow - reddishSolubility
Physical state @ 20°CNot available.
yellow.)
Not available.
Specific Gravity
Molecular Weight262.11Partition CoefficientNot available.
Boiling PointNot available.Not available.
Vapor Pressure
Melting PointNot available.Vapor DensityNot available.
Not available.Not available.
Refractive IndexVolatility
Critical TemperatureNot available.OdorNot available.
Not available.Not available.
ViscosityTaste

Section X.Stability and Reactivity Data

This material is stable if stored under proper conditions. (See Section VII for instructions)
Stability
Conditions of InstabilityAvoid excessive heat and light.
IncompatibilitiesReactive with oxidizing agents.

Section XI. Toxicological Information
RTECS NumberNot available.
Eye Contact. Ingestion. Inhalation.
Routes of Exposure
Not available.
Toxicity Data
CARCINOGENIC EFFECTS : Not available.
Chronic Toxic Effects
MUTAGENIC EFFECTS : Not available.
TERATOGENIC EFFECTS : Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure to this compound is not known to aggravate existing medical conditions.
No specific information is available in our data base regarding the toxic effects of this material for humans. However,
Acute Toxic Effects
exposure to any chemical should be kept to a minimum. Skin and eye contact may result in irritation. May be harmful if
inhaled or ingested. Always follow safe industrial hygiene practices and wear proper protective equipment when handling this
compound.

Section XII.Ecological Information
EcotoxicityNot available.
Environmental FateNot available.
Continued on Next Page
Ethyl 2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoate

Section XIII. Disposal Considerations
Waste DisposalRecycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
federal, state and local regulations when disposing of the substance.

Section XIV. Transport Information
Not a DOT controlled material (United States).
DOT Classification
PIN NumberNot applicable.
Proper Shipping NameNot applicable.
Packing Group (PG)Not applicable.
DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
TSCA Chemical InventoryThis product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
CFR 720.36 (C) for those products not on the inventory list:
(EPA)
(i) These products are supplied solely for use in research and development by or under the supervision of a technically
qualified individual as defined in 40 CFR 720.0 et sec.
(ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
supplied on an MSDS sheet.
WHMIS ClassificationNot controlled under WHMIS (Canada).
(Canada)
EINECS Number (EEC)Not available.
EEC Risk StatementsNot available.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

HS Code 2934999090

 Synthetic Route

~%

HSL-IN-3 Structure

HSL-IN-3

CAS#:346656-34-6

Literature: Organic Letters, , vol. 3, # 10 p. 1435 - 1437

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Ethyl 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate
2-(2-Ethoxycarbonylphenyl)-5,5-dimethyl-1,3,2-dioxaborinane
2-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)benzoic Acid Ethyl Ester
Benzoic acid, 2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-, ethyl ester
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Price: ¥1442/10 mM * 1 mL in DMSO

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