CAY10598

Modify Date: 2024-01-08 19:04:52

CAY10598 Structure
CAY10598 structure
Common Name CAY10598
CAS Number 346673-06-1 Molecular Weight 383.487
Density 1.2±0.1 g/cm3 Boiling Point 632.0±65.0 °C at 760 mmHg
Molecular Formula C21H29N5O2 Melting Point N/A
MSDS N/A Flash Point 336.0±34.3 °C

 Use of CAY10598


TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases[1].

 Names

Name 5-(3-hydroxy-4-phenylbut-1-enyl)-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one
Synonym More Synonyms

 CAY10598 Biological Activity

Description TCS 2510 is a selective EP4 agonist. TCS 2510 can be used for the research of metabolic diseases[1].
Related Catalog
Target

EP4

In Vitro TCS 2510 (0.001~100 μM; GLUTag cells) stimulates glucagon like peptide 1 secretion. TCS2510 activates the Gas signaling pathway. TCS 2510 (10 μM; 2~24 h; GLUTag cells) increases the Gcg mRNA expression levels. TCS 2510 produces a concentration dependent increase in cAMP levels in GLUTag cells with EC50 of 20 nM and the maximal stimulation of 60 % over the basal cAMP levels. The decrease in cell impedance in GLUTag cells observed with TCS 2510 is concentration dependent with IC50 of 15 nM. TCS 2510 produces a concentration-dependent increase in glucagon like peptide 2 secretion in GLUTag cells[1].
In Vivo TCS 2510 (0.1~10 mg/kg; p.o.) produces a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration[1]. TCS 2510 (10 mg/kg; p.o.) increases plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels[1]. TCS 2510 (1~10 mg/kg; p.o) affords a significant elevation in plasma glucagon like peptide 2 levels[1] Animal Model: Mice[1] Dosage: 0.1~10 mg/kg Administration: P.o. Result: Produced a dose-dependent elevation in plasma glucagon like peptide 1 levels in fasted mice measured 15 min after compound administration. Animal Model: Mice[1] Dosage: 10 mg/kg Administration: P.o. Result: Increased plasma glucagon like peptide 1 levels up to 8-fold over the basal hormone levels. Animal Model: Mice[1] Dosage: 1~10 mg/kg Administration: P.o. Result: Afforded a significant elevation in plasma glucagon like peptide 2 levels.
References

[1]. Coskun T, et al. Activation of prostaglandin E receptor 4 triggers secretion of gut hormone peptides GLP-1, GLP-2, and PYY. Endocrinology. 2013;154(1):45-53.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 632.0±65.0 °C at 760 mmHg
Molecular Formula C21H29N5O2
Molecular Weight 383.487
Flash Point 336.0±34.3 °C
Exact Mass 383.232117
PSA 95.00000
LogP 1.51
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.626

 Synonyms

2-Pyrrolidinone, 5-[(1E,3S)-3-hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-, (5R)-
(5R)-5-[(1E,3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone