7ß-Hydroxycholesterol-d7

Modify Date: 2024-01-04 11:45:36

7ß-Hydroxycholesterol-d7 Structure
7ß-Hydroxycholesterol-d7 structure
Common Name 7ß-Hydroxycholesterol-d7
CAS Number 349553-97-5 Molecular Weight 409.70
Density 1.0±0.1 g/cm3 Boiling Point 503.4±38.0 °C at 760 mmHg
Molecular Formula C27H39D7O2 Melting Point N/A
MSDS N/A Flash Point 211.8±21.4 °C

 Use of 7ß-Hydroxycholesterol-d7


7ß-Hydroxycholesterol-d7 is the deuterium labeled 7α-Hydroxycholesterol. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1][2].

 Names

Name 7beta-hydroxycholesterol-25,26,26,26,27,27,27-d7
Synonym More Synonyms

 7ß-Hydroxycholesterol-d7 Biological Activity

Description 7ß-Hydroxycholesterol-d7 is the deuterium labeled 7α-Hydroxycholesterol. 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 503.4±38.0 °C at 760 mmHg
Molecular Formula C27H39D7O2
Molecular Weight 409.70
Flash Point 211.8±21.4 °C
Exact Mass 388.334137
PSA 40.46000
LogP 7.41
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.539

 Synonyms

7-Hydroxy Cholesterol-d7
(3S,7R,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-[(2R)-5-methyl-2-hexanyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol (non-preferred name)
5-Cholestene-3,7-diol-d7
Cholest-5-ene-3,7-diol-d7
7-Hydroxycholest-5-en-3-ol-d7