7Beta-Hydroxycholesterol

Modify Date: 2024-01-02 14:43:05

7Beta-Hydroxycholesterol structure	Common Name	7Beta-Hydroxycholesterol
	CAS Number	566-27-8	Molecular Weight	402.653
	Density	1.0±0.1 g/cm3	Boiling Point	515.3±38.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₄₆O₂	Melting Point	165-167ºC
	MSDS	Chinese USA	Flash Point	214.7±21.4 °C

Use of 7Beta-Hydroxycholesterol

7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1].

Name	7β-hydroxycholesterol
Synonym	More Synonyms

Description	7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.

Density	1.0±0.1 g/cm3
Boiling Point	515.3±38.0 °C at 760 mmHg
Melting Point	165-167ºC
Molecular Formula	C₂₇H₄₆O₂
Molecular Weight	402.653
Flash Point	214.7±21.4 °C
Exact Mass	402.349792
PSA	40.46000
LogP	7.94
Vapour Pressure	0.0±3.0 mmHg at 25°C
Index of Refraction	1.536

7Beta-Hydroxycholesterol MSDS(Chinese)

Safety Phrases	S22-S26
RIDADR	NONH for all modes of transport

Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers.

Br. J. Nutr. 114 , 368-75, (2015)

Toxic oxysterols in a hypercholesterolaemia-relevant proportion cause suicidal death of human erythrocytes or eryptosis. This process proceeds through early production of reactive oxygen species (ROS)...

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes.

Biochem. Pharmacol. 86(1) , 67-79, (2013)

There is some evidence that oxidized derivatives of cholesterol, 7-ketocholesterol (7KC) and 7β-hydroxycholesterol (7βOHC), are increased in the plasma of patients with neurodegenerative diseases asso...

[Cerebrotendinous xanthomatosis is a rare disorder, which requires a specific treatment].

Ugeskr. Laeg. 175(5) , 285-6, (2013)

Cerebrotendinous xanthomatosis (CTX) is a rare, but treatable lipid storage disorder caused by mutation in the CYP27A1 gene. The disorder results in deposition of cholestanol in various tissues. The c...

5-Cholestene-3β,7β-diol

7β-hydroxycholesterol

7BETA-HYDROXYCHOLESTEROL

Cholest-5-ene-3,7-diol, (3β,7β,8ξ)-

7β-Hydroxy Cholesterol

(3β,7β,8ξ)-Cholest-5-ene-3,7-diol