TQS
Modify Date: 2025-08-25 15:04:58
TQS structure
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Common Name | TQS | ||
|---|---|---|---|---|
| CAS Number | 353483-92-8 | Molecular Weight | 376.47100 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TQSTQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain[1]. |
| Name | 4-(1-Naphthyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-s ulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | TQS is a α7 nicotinic acetylcholine receptor (nAChR) positive allosteric modulator. TQS can be used for the research of neuroinflammatory pain[1]. |
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| Related Catalog | |
| Target |
nAChR[1] |
| In Vivo | TQS (1 or 4 mg/kg; i.p.) reduces the expression of LPS-induced IκB mRNA, CD11b mRNA and regulates microglial morphological changes in the hippocampus[1]. Animal Model: Male C57BL/6J mice[1] Dosage: 1 or 4 mg/kg Administration: I.p. Result: Reduced the expression of LPS-induced IκB mRNA, CD11b mRNA and regulated microglial morphological changes in the hippocampus. |
| References |
| Molecular Formula | C22H20N2O2S |
|---|---|
| Molecular Weight | 376.47100 |
| Exact Mass | 376.12500 |
| PSA | 80.57000 |
| LogP | 6.23280 |
| InChIKey | SIZWDJIHABLBSP-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1ccc2c(c1)C1C=CCC1C(c1cccc3ccccc13)N2 |
| Hazard Codes | Xi |
|---|
| PSB 11 hydrochloride |