9-Hydroxycalabaxanthone
Modify Date: 2025-08-25 17:44:04
9-Hydroxycalabaxanthone structure
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Common Name | 9-Hydroxycalabaxanthone | ||
|---|---|---|---|---|
| CAS Number | 35349-68-9 | Molecular Weight | 408.444 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 617.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C24H24O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 213.9±25.0 °C | |
Use of 9-Hydroxycalabaxanthone9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM)[1]. |
| Name | 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H ,6H-pyrano[3,2-b]xanthen-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | 9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM)[1]. |
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| Related Catalog | |
| In Vitro | 9-Hydroxycalabaxanthone inhibits the activities of 3D7 and K1 P. falciparum clones with IC50 values of 1.5 μM and 1.2 μM, respectively[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 617.6±55.0 °C at 760 mmHg |
| Molecular Formula | C24H24O6 |
| Molecular Weight | 408.444 |
| Flash Point | 213.9±25.0 °C |
| Exact Mass | 408.157288 |
| PSA | 89.13000 |
| LogP | 6.17 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.618 |
| InChIKey | HQWHKELJHUFLGD-UHFFFAOYSA-N |
| SMILES | COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4 |
| Hazard Codes | Xi |
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| Precursor 1 | |
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| DownStream 0 | |
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Name: Inhibition of human IDH1 expressed in IPTG-induced Escherichia coli BL21 cells assess...
Source: ChEMBL
Target: Isocitrate dehydrogenase [NADP] cytoplasmic
External Id: CHEMBL3635922
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Name: Inhibition of human IDH1 R132H mutant expressed in IPTG-induced Escherichia coli BL21...
Source: ChEMBL
Target: Isocitrate dehydrogenase [NADP] cytoplasmic
External Id: CHEMBL3635921
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Name: Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucosid...
Source: ChEMBL
Target: Maltase-glucoamylase
External Id: CHEMBL4344045
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Name: Inhibition of Clostridium perfringens neuraminidase by fluorimetry
Source: ChEMBL
Target: Sialidase
External Id: CHEMBL1225721
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Name: Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISA
Source: ChEMBL
Target: Transcription factor p65
External Id: CHEMBL1100043
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|
Name: Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 h...
Source: ChEMBL
Target: RAW264.7
External Id: CHEMBL4344044
|
|
Name: Cytotoxicity against human HT-29 cells
Source: ChEMBL
Target: HT-29
External Id: CHEMBL1100042
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Name: Competitive inhibition of Clostridium perfringens neuraminidase by fluorimetry
Source: ChEMBL
Target: Sialidase
External Id: CHEMBL1225719
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Name: Inhibition of p50 after 1 hr by ELISA
Source: ChEMBL
Target: Nuclear factor NF-kappa-B p105 subunit
External Id: CHEMBL1100041
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Name: Inhibition of recombinant PDE4D2 (86 to 413 residues) (unknown origin) expressed in E...
Source: ChEMBL
Target: 3',5'-cyclic-AMP phosphodiesterase 4D
External Id: CHEMBL5339428
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| 1-isomangostin hydrate |
| 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one |
| 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one |
| 9-Hydroxycalabaxanthone |