9-Hydroxycalabaxanthone

Modify Date: 2024-01-04 20:09:31

9-Hydroxycalabaxanthone Structure
9-Hydroxycalabaxanthone structure
Common Name 9-Hydroxycalabaxanthone
CAS Number 35349-68-9 Molecular Weight 408.444
Density 1.3±0.1 g/cm3 Boiling Point 617.6±55.0 °C at 760 mmHg
Molecular Formula C24H24O6 Melting Point N/A
MSDS N/A Flash Point 213.9±25.0 °C

 Use of 9-Hydroxycalabaxanthone


9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM)[1].

 Names

Name 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H ,6H-pyrano[3,2-b]xanthen-6-one
Synonym More Synonyms

 9-Hydroxycalabaxanthone Biological Activity

Description 9-Hydroxycalabaxanthone (Xanthone I) is a known xanthone isolated from Garcinia mangostana Linn. 9-Hydroxycalabaxanthone has quorum-sensing inhibitory, anti-microbial, and anti-malarial activities (IC50=1.2-1.5 µM)[1].
Related Catalog
In Vitro 9-Hydroxycalabaxanthone inhibits the activities of 3D7 and K1 P. falciparum clones with IC50 values of 1.5 μM and 1.2 μM, respectively[1].
References

[1]. Gamal A Mohamed, et al. Mangostanaxanthones I and II, New Xanthones From the Pericarp of Garcinia Mangostana. Fitoterapia. 2014 Oct;98:215-21.

[2]. Wanna Chaijaroenkul,  et al. The in Vitro Antimalarial Interaction of 9-hydroxycalabaxanthone and α-mangostin With mefloquine/artesunate. Acta Parasitol. 2014 Mar;60(1):105-11.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 617.6±55.0 °C at 760 mmHg
Molecular Formula C24H24O6
Molecular Weight 408.444
Flash Point 213.9±25.0 °C
Exact Mass 408.157288
PSA 89.13000
LogP 6.17
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.618

 Safety Information

Hazard Codes Xi

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-
1-isomangostin hydrate
2H,6H-Pyrano[3,2-b]xanthen-6-one, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-butenyl)-
5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one
5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one
9-Hydroxycalabaxanthone
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