氧杂蒽酮I

• 常用名: 氧杂蒽酮I
• 英文名: 9-Hydroxycalabaxanthone
• CAS号: 35349-68-9
• 分子量: 408.444
• 密度: 1.3±0.1 g/cm3
• 沸点: 617.6±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₄O₆
• 熔点: N/A
• 闪点: 213.9±25.0 °C

氧杂蒽酮I用途

9-Hydroxycalabaxanthone (Xanthone I) 是一种黄酮类物质,从 Garcinia mangostana 中分离得到的。9-Hydroxycalabaxanthone 具有群体感抑菌、抗菌和抗疟活性 (IC50=1.2-1.5 µM)。

氧杂蒽酮I名称

• 中文名: 氧杂蒽酮 I
• 英文名: 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H ,6H-pyrano[3,2-b]xanthen-6-one

氧杂蒽酮I生物活性

• 描述: 9-Hydroxycalabaxanthone (Xanthone I) 是一种黄酮类物质,从 Garcinia mangostana 中分离得到的。9-Hydroxycalabaxanthone 具有群体感抑菌、抗菌和抗疟活性 (IC50=1.2-1.5 µM)。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 体外研究: 9-羟基卡拉巴杂蒽酮抑制恶性疟原虫3D7和K1克隆的活性,IC50值分别为1.5μM和1.2μM[1]。
• 参考文献:

  [1]. Gamal A Mohamed, et al. Mangostanaxanthones I and II, New Xanthones From the Pericarp of Garcinia Mangostana. Fitoterapia. 2014 Oct;98:215-21.

  [2]. Wanna Chaijaroenkul, et al. The in Vitro Antimalarial Interaction of 9-hydroxycalabaxanthone and α-mangostin With mefloquine/artesunate. Acta Parasitol. 2014 Mar;60(1):105-11.

氧杂蒽酮I物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 617.6±55.0 °C at 760 mmHg
• 分子式: C₂₄H₂₄O₆
• 分子量: 408.444
• 闪点: 213.9±25.0 °C
• 精确质量: 408.157288
• PSA: 89.13000
• LogP: 6.17
• InChIKey: HQWHKELJHUFLGD-UHFFFAOYSA-N
• SMILES: COc1c(O)cc2oc3cc4c(c(O)c3c(=O)c2c1CC=C(C)C)C=CC(C)(C)O4
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.618
• 储存条件: 2-8℃，干燥，密闭

氧杂蒽酮I安全信息

• 危害码 (欧洲): Xi

氧杂蒽酮I靶点实验

查看更多实验

实验名称：Inhibition of human IDH1 expressed in IPTG-induced Escherichia coli BL21 cells assess... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL3635922

实验名称：Inhibition of human IDH1 R132H mutant expressed in IPTG-induced Escherichia coli BL21... 来源：ChEMBL 靶标：Isocitrate dehydrogenase [NADP] cytoplasmic External Id：CHEMBL3635921

实验名称：Inhibition of alpha-glucosidase (unknown origin) using p-nitrophenyl alpha-D-glucosid... 来源：ChEMBL 靶标：Maltase-glucoamylase External Id：CHEMBL4344045

实验名称：Inhibition of Clostridium perfringens neuraminidase by fluorimetry 来源：ChEMBL 靶标：Sialidase External Id：CHEMBL1225721

实验名称：Inhibition of nuclear factor NF-kappa-B p65 subunit after 1 hr by ELISA 来源：ChEMBL 靶标：Transcription factor p65 External Id：CHEMBL1100043

实验名称：Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells incubated for 24 h... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4344044

实验名称：Cytotoxicity against human HT-29 cells 来源：ChEMBL 靶标：HT-29 External Id：CHEMBL1100042

实验名称：Competitive inhibition of Clostridium perfringens neuraminidase by fluorimetry 来源：ChEMBL 靶标：Sialidase External Id：CHEMBL1225719

实验名称：Inhibition of p50 after 1 hr by ELISA 来源：ChEMBL 靶标：Nuclear factor NF-kappa-B p105 subunit External Id：CHEMBL1100041

实验名称：Inhibition of recombinant PDE4D2 (86 to 413 residues) (unknown origin) expressed in E... 来源：ChEMBL 靶标：3',5'-cyclic-AMP phosphodiesterase 4D External Id：CHEMBL5339428

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氧杂蒽酮I英文别名

• 1-isomangostin hydrate
• 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methyl-2-buten-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one
• 5,9-Dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-2H,6H-pyrano[3,2-b]xanthen-6-one
• 9-Hydroxycalabaxanthone