FLUOCINONIDE
Modify Date: 2024-01-02 22:44:25
FLUOCINONIDE structure
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Common Name | FLUOCINONIDE | ||
|---|---|---|---|---|
| CAS Number | 356-12-7 | Molecular Weight | 494.525 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 591.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C26H32F2O7 | Melting Point | 309ºC | |
| MSDS | Chinese USA | Flash Point | 311.3±30.1 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of FLUOCINONIDEFluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.Target: Glucocorticoid ReceptorFluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. Fluocinonide ranks as a "high-potency" topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects. Fluocinonide should not be used if infection is present. Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs. Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure. From Wikipedia. |
| Name | Fluocinolone Acetonide Acetate |
|---|---|
| Synonym | More Synonyms |
| Description | Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders.Target: Glucocorticoid ReceptorFluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. Fluocinonide ranks as a "high-potency" topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects. Fluocinonide should not be used if infection is present. Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs. Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure. From Wikipedia. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.1±50.0 °C at 760 mmHg |
| Melting Point | 309ºC |
| Molecular Formula | C26H32F2O7 |
| Molecular Weight | 494.525 |
| Flash Point | 311.3±30.1 °C |
| Exact Mass | 494.211609 |
| PSA | 99.13000 |
| LogP | 3.36 |
| Vapour Pressure | 0.0±3.8 mmHg at 25°C |
| Index of Refraction | 1.560 |
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Section 1. Chemical Product and Company Identification Fluocinonide Common Name/ Trade Name Fluocinonide Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Get medical attention. Skin ContactIn case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention. Serious Skin ContactWash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate medical attention. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationEvacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or waistband. Seek medical attention. IngestionIf swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical attention immediately. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsNot available. Flammable LimitsNot available. Products of CombustionThese products are carbon oxides (CO, CO2), halogenated compounds. Fire Hazards in Presence of Slightly flammable to flammable in presence of heat. Various SubstancesNon-flammable in presence of shocks. Explosion Hazards in Presence Slightly explosive in presence of open flames and sparks. of Various SubstancesNon-explosive in presence of shocks. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onWhen heated to decomposition it emits toxic fumes. As with most organic solids, fire is possible at elevated Fire Hazardstemperatures Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust Hazardsexplosion hazard. Section 6. Accidental Release Measures Small SpillUse appropriate tools to put the spilled solid in a convenient waste disposal container. Large SpillPoisonous solid. Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all ignition Fluocinonide Section 7. Handling and Storage PrecautionsKeep locked up.. Keep away from heat. Keep away from sources of ignition. Do not ingest. Do not breathe dust. Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes. StorageKeep container tightly closed. Keep container in a cool, well-ventilated area. Section 8. Exposure Controls/Personal Protection Engineering ControlsUse process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants below the exposure limit. Personal ProtectionSplash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves. Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used a Large Spillto avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Solid. (Powdered solid.)OdorNot available. TasteNot available. Molecular Weight494.54 g/mole ColorWhite. pH (1% soln/water)Not applicable. Not available. Boiling Point Melting Point300°C (572°F) Not available. Critical Temperature Specific GravityNot available. Vapor PressureNot applicable. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Water/Oil Dist. Coeff.Not available. Ionicity (in Water)Not available. Dispersion PropertiesNot available. SolubilityInsoluble in cold water, hot water. Soluble in ethanol Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, dust generation Incompatibility with variousNot available. substances CorrosivityNon-corrosive in presence of glass. Fluocinonide Special Remarks onNot available. Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Section 11. Toxicological Information Routes of EntryAbsorbed through skin. Dermal contact. Inhalation. Ingestion. Toxicity to AnimalsAcute oral toxicity (LD50): 14 mg/kg [Rat]. Chronic Effects on Humans Not available. Other Toxic Effects onVery hazardous in case of ingestion. HumansHazardous in case of skin contact (irritant, permeator), of inhalation. Special Remarks onNot available. Toxicity to Animals Special Remarks onMay cause adverse reproductive effects. Chronic Effects on HumansMay affect genetic material (mutagenic) Special Remarks on otherPotential Health Effects: Toxic Effects on HumansSkin: Skin contact may cause skin irritation witn burning, itching, dryness, Folliculitis, Hypertrichosis, acneform eruptions, Hypopigmentation, Perioral dermatitis. May also cause allergic contact dermatitis, skin atrophy (loss of skin collegan), maceration of the skin, secondary infection, Striae, Miliaria. Topical corticosteroids can be absorbed through the skin in sufficient amounts to produce systemic effects (see ingestion) Eyes: May cause eye irritaiton, corneal ulcers and visual disturbances Inhalation: May be harmful if inhaled. It may be irritating to the mucous membranes and upper respiratory tract. Ingestion: May be fatal if swallowed. It may affect blood (changes is leukocyte count, changes in bone marrow), and metabolism (weight loss), cardiovascular system (hypertension, cardiac failure). It may also cause edema Note: Systemic absorption of topical corticosteroids has produced reversible hypothalmic-pituitary-adrenal (HPA) axid supression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some individuals. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Possibly hazardous short term degradation products are not likely. However, long term degradation products may Products of Biodegradation arise. The products of degradation are as toxic as the product itself. Toxicity of the Products of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Fluocinonide Section 14. Transport Information DOT ClassificationCLASS 6.1: Poisonous material. Identification: Toxic solid, organic, n.o.s. (Fluocinonide) UNNA: 2811 PG: II Not available. Special Provisions for Transport DOT (Pictograms) Section 15. Other Regulatory Information and Pictograms No products were found. Federal and State Regulations California Proposition 65 Warnings Other RegulationsOSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200). EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances. WHMIS (Canada) Not controlled under WHMIS (Canada). Other Classifications DSCL (EEC)R28- Very toxic if swallowed.S22- Do not breathe dust. R63- Possible risk of harm to theS25- Avoid contact with eyes. unborn child.S36/37/39- Wear suitable protective clothing, gloves and eye/face protection. S45- In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 2 0 Reactivity Health Reactivity 0 Specific hazard Personal Protection E WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) Fluocinonide ADR (Europe) (Pictograms) Protective Equipment Gloves. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. SECTION 16 - ADDITIONAL INFORMATION N/A |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H361 |
| Precautionary Statements | Missing Phrase - N15.00950417-P280 |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | R28 |
| Safety Phrases | 22-25-28-36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| WGK Germany | 3 |
| RTECS | TU3831000 |
| Packaging Group | I |
| Hazard Class | 6.1(a) |
| HS Code | 2937210000 |
CAS#:67-73-2
CAS#:108-24-7
CAS#:3932-49-8| HS Code | 2937210000 |
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Effects of a novel formulation of fluocinonide 0.1% cream on skin barrier function in atopic dermatitis.
Journal. of. Drugs in. Dermatology. 10(2) , 171-6, (2011) To determine the effect a novel formulation of fluocinonide cream on skin barrier function in subjects with atopic dermatitis.The authors performed an open-label, investigator-blinded, side-by-side, c... |
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Urticarial hypersensitivity reaction caused by temozolomide.
Journal. of. Drugs in. Dermatology. 9(9) , 1142-4, (2010) Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently under clinical investigation for the treatment of brain metastases from... |
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In vivo determination of the skin atrophy potential of the super-high-potency topical corticosteroid fluocinonide 0.1% cream compared with clobetasol propionate 0.05% cream and foam, and a vehicle.
Journal. of. Drugs in. Dermatology. 7(1) , 28-32, (2008) Prolonged topical corticosteroid use is often associated with atrophic skin changes. This trial compared signs of skin atrophy related to 3 super-high-potency corticosteroids: fluocinonide 0.1% cream,... |
| 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluor-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxo |
| Ethylacetat |
| acétate de 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-6 |
| 16a,17a-Isopropylidene-6a-fluorotriamcinolone 21-Acetate |
| 6a,9-Difluoro-11b,16a,17,21-tetrahydroxypregna-1,4-diene-3,20-dione Cyclic 16,17-Acetal with Acetone 21-Acetate |
| FLUOCINONIDE |
| 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-ox |
| 2H-naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-[(acetyloxy)acetyl]-4b,12-difluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)- |
| 2H-Naphth[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, 6b-[2-(acetyloxy)acetyl]-4b,12-difluoro-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-5-hydroxy-4a,6a,8,8-tetramethyl-, (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)- |
| 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluor-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethylacetat |
| 21-Acetoxy-6a,9a-difluoro-11b-hydroxy-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione |
| oethyl acetate |
| 21-(Acetyloxy)-6a,9-difluoro-11b-hydroxy-16a,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione |
| Topsym |
| acétate de 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-5-hydroxy-4a,6a,8,8-tétraméthyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodécahydro-6bH-naphto[2',1':4,5]indéno[1,2-d][1,3]dioxol-6b-yl]-2-oxoéthyle |
| 2-[(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-Difluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl]-2-oxoethyl acetate |