(2H)Formamide

Modify Date: 2024-01-04 09:15:55

(2H)Formamide Structure
(2H)Formamide structure
Common Name (2H)Formamide
CAS Number 35692-88-7 Molecular Weight 46.047
Density 1.0±0.1 g/cm3 Boiling Point 210.5±9.0 °C at 760 mmHg
Molecular Formula CH2DNO Melting Point 2-3ºC(lit.)
MSDS Chinese USA Flash Point 81.1±18.7 °C
Symbol GHS08
GHS08
Signal Word Danger

 Use of (2H)Formamide


Formamide-d1 is the deuterium labeled Formamide[1]. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.

 Names

Name deuterioformamide
Synonym More Synonyms

 (2H)Formamide Biological Activity

Description Formamide-d1 is the deuterium labeled Formamide[1]. Formamide is an amide derived from formic acid and has been used as solvent for many ionic compounds.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 210.5±9.0 °C at 760 mmHg
Melting Point 2-3ºC(lit.)
Molecular Formula CH2DNO
Molecular Weight 46.047
Flash Point 81.1±18.7 °C
Exact Mass 46.027740
PSA 43.09000
LogP -1.51
Vapour Pressure 0.2±0.4 mmHg at 25°C
Index of Refraction 1.370

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H351-H360D-H373
Precautionary Statements P201-P260-P280-P308 + P313
Target Organs Blood
Hazard Codes T: Toxic;
Risk Phrases 61-37/38-41
Safety Phrases 53-23-26-36/37/39-45
RIDADR NONH for all modes of transport

 Synthetic Route

~97%

(2H)Formamide Structure

(2H)Formamide

CAS#:35692-88-7

Literature: Threadgill, Michael D.; Gledhill, Adrian P. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 873 - 876

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(2H)Formamide Structure

(2H)Formamide

CAS#:35692-88-7

Literature: Ha, Jeong-Hyon; Kim, Yung Sam; Hochstrasser, Robin M. Journal of Chemical Physics, 2006 , vol. 124, # 6 art. no. 064508

 Synonyms

(H)Formamide
C-Deuterio-formamid
d1-N,N-formamide
Formamide-1-d
Formamide-d
formamide-d1
MFCD01074135
C-deuterio-formamide