Naloxone HCl
Modify Date: 2026-07-12 10:59:49
Naloxone HCl structure
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Common Name | Naloxone HCl | ||
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| CAS Number | 357-08-4 | Molecular Weight | 363.84 | |
| Density | N/A | Boiling Point | 532.8ºC at 760 mmHg | |
| Molecular Formula | C19H22ClNO4 | Melting Point | 200-2050C | |
| MSDS | N/A | Flash Point | 276.1ºC | |
Use of Naloxone HClNaloxone hydrochloride is a potent opioid receptor antagonist. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Naloxone Hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Naloxone hydrochloride is a potent opioid receptor antagonist. |
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| Related Catalog | |
| In Vivo | Naloxone (2.0 mg/kg with constant infusion of 1.7 mg/kg/h) causes a significant improvement in neurobehavioral outcome which persists up to 4 weeks postinjury in rat. Naloxone treatment causes a modest and nonsignificant increase in mean arterial blood pressure (MAP)[1]. Naloxone (0.4 mg/kg) causes memory facilitation and antagonizes the amnestic effect of ACTH and epinephrine in rat[2]. Naloxone treatment diminishes the strength of the initial tetanus in a dose-related manner in cats. Naloxone (5 or 10 mg/kg, i.v.) causes subsequent doses of morphine to produce less PTP depression but has no effect on maximal twitch depression[3]. |
| Animal Admin | Young adult Wistar rats are used in the assay: females for experiments l and 3 (age 50-70 days, weight 100-185 g) and males for experiments 2 and 4 (age 51-69 days, weight 140-200 g). The same apparatus is used for both: a 50×25×25 cm box made of plywood with a frontal glass wall, whose floor consists of 1 mm-caliber bronze bars spaced l0 mm apart. In task l, a 5 cm high, 25×25 cm wooden platform is introduced into the box so as to cover the left half of the grid. Rats are held gently by their bodies and loared onto the platform facing the rear left corner, at which time a quartz chronometer is activated. Time is counted until the animals stepped down from the platform and placed their four paws on the grid, upon which a 0.5 mA, 60 Hz footshock is continuously delivered until the animals return to the platform. In task 2 the platform is only 7 cm wide and covered only the leftmost seven bars of the grid; the footshock is of only 0.3 mA and is delivered in 0.4 msec pulses once every 2 sec until the animals climb back onto the platform. Immediately after training in each task the animals are withdrawn from the box injected i.p. with one of the following: saline (1.0 mL/kg), ACTH1-24 (0.2 or 2.0 μg/kg), epinephrine HCl (5.0 or 50.0 μg/kg), human β-endorphin (0.1 or 1.0 μg/kg), naloxone HCl (0.4 mg/kg), or ACTH or epinephrine given together with either β-endorphin or naloxone. All drugs are dissolved in saline to an injection volume of 1.0 mL/kg. Twenty-four hr after training the animals again are placed on the platform (the wide one for task 1, experiments 1 and 2, and the narrow one for task 2, experiments 3 and 4), and their latency to stepdown onto the grid again is measured as in the training session. A ceiling of 180 sec is imposed on this measure. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 532.8ºC at 760 mmHg |
|---|---|
| Melting Point | 200-2050C |
| Molecular Formula | C19H22ClNO4 |
| Molecular Weight | 363.84 |
| Flash Point | 276.1ºC |
| Exact Mass | 363.123749 |
| PSA | 70.00000 |
| LogP | 2.04130 |
| InChIKey | RGPDIGOSVORSAK-STHHAXOLSA-N |
| SMILES | C=CCN1CCC23c4c5ccc(O)c4OC2C(=O)CCC3(O)C1C5.Cl |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light. |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25-S26-S36/37/39 |
| WGK Germany | 3 |
This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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Naloxone HCl CAS#:357-08-4 |
| Literature: US2003/69263 A1, ; |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 1 | |
CAS#:465-65-6This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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Name: Induction of neurosphere phenotype changes in mouse neural precursor cells at 3 uM
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266186
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Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: Inhibition of neurosphere proliferation of mouse neural precursor cells by MTT assay
Source: ChEMBL
Target: N/A
External Id: CHEMBL1266185
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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Name: The ability to reverse an ED50 dose of morphine when tested in mice by the tail-flick...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL714774
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Name: Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4296184
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Name: The ability to reverse an ED50 dose of morphine when tested in mice by the tail-flick...
Source: ChEMBL
Target: Mus musculus
External Id: CHEMBL713003
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| (5α)-3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5-epoxymorphinan-6-one hydrochloride (1:1) |
| (1S,5R,13R,17S)-10,17-dihydroxy-4-prop-2-en-1-yl-12-oxa-4-azapentacyclo[9.6.1.0.0.0]octadeca-7(18),8,10-trien-14-one hydrochloride |
| (5α)-17-Allyl-4,5-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
| Morphinan-6-one, 17-allyl-4,5-α-epoxy-3,14-dihydroxy-, hydrochloride |
| Narcanti |
| MFCD00069322 |
| 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
| Naloxone hydrochloride |
| Nalone |
| morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5α)-, hydrochloride |
| 17-Allyl-4,5-a-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride |
| 17-Allyl-4,5-α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride |
| NALOXONE HCL |
| (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-one,hydrochloride |
| (-)-N-Allyl-14-hydroxynordihydromorphinone hydrochloride |
| EINECS 206-611-0 |
| (5α)-17-Allyl-3,14-dihydroxy-4,5-epoxymorphinan-6-one hydrochloride (1:1) |
| Narcan |
| (5α)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one hydrochloride |
| UNII-F850569PQR |
| Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propen-1-yl)-, (5α)-, hydrochloride (1:1) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the safety information for Naloxone Hydrochloride? |
| A: Safety information for Naloxone Hydrochloride: S22-S24/25-S26-S36/37/39. |
| Q: What is the LogP of Naloxone Hydrochloride? |
| A: LogP of Naloxone Hydrochloride is 2.04130. |
| Q: What is the molecular formula of Naloxone Hydrochloride? |
| A: Molecular formula of Naloxone Hydrochloride is C19H22ClNO4. |
| Q: What are the upstream materials of Naloxone Hydrochloride? |
| A: Related upstream materials(CAS) of Naloxone Hydrochloride: 124-90-3. |
| Q: What are the uses of Naloxone Hydrochloride? |
| A: Main uses of Naloxone Hydrochloride: Naloxone hydrochloride is a potent opioid receptor antagonist. |
| Q: What are the downstream products of Naloxone Hydrochloride? |
| A: Related downstream products(CAS) of Naloxone Hydrochloride: 465-65-6. |
| Q: What is the InChIKey of Naloxone Hydrochloride? |
| A: InChIKey of Naloxone Hydrochloride is RGPDIGOSVORSAK-STHHAXOLSA-N. |
| Q: What is the boiling point of Naloxone Hydrochloride? |
| A: Boiling point of Naloxone Hydrochloride is 532.8ºC at 760 mmHg. |
| Q: What is the melting point of Naloxone Hydrochloride? |
| A: Melting point of Naloxone Hydrochloride is 200-2050C. |
| Q: What is the polar surface area (PSA) of Naloxone Hydrochloride? |
| A: Polar surface area (PSA) of Naloxone Hydrochloride is 70.00000. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Henan Tianfu Chemical Co., Ltd. |