Cefaloglycin

Modify Date: 2026-07-12 14:32:35

Cefaloglycin structure	Common Name	Cefaloglycin
	CAS Number	3577-01-3	Molecular Weight	405.42500
	Density	1.52 g/cm3	Boiling Point	761.8ºC at 760mmHg
	Molecular Formula	C₁₈H₁₉N₃O₆S	Melting Point	236.5°C (rough estimate)
	MSDS	N/A	Flash Point	414.5ºC

Use of Cefaloglycin

Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration[1][2][3].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	cefaloglycin
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Gram-Positive cocci[2]
In Vitro	Cefaclor to be comparable to Cephaloglycin in terms of in vitro activity against S. pyogenes and somewhat superior to Cephalexin[2].
In Vivo	Respiration with and the uptake of succinate and ADP are measured in rabbit renal cortical mitochondria exposed for 2 to 6 h to 300 to 3,000 µg of Cefaloglycin (Cephaloglycin) per mL and then washed to remove the antibiotic. Cefaloglycin (Cephaloglycin) irreversibly reduces both respiration and succinate uptake. The pattern of in vitro injury of Cefaloglycin to mitochondrial substrate uptake and respiration evolves in a time-dependent and concentration-dependent manner[1].
References	[1]. B M Tune, et al. The Renal Mitochondrial Toxicity of Beta-Lactam Antibiotics: In Vitro Effects of Cephaloglycin and Imipenem. J Am Soc Nephrol. 1990 Nov;1(5):815-21. [2]. S Shadomy, et al. In Vitro Activities of Five Oral Cephalosporins Against Aerobic Pathogenic Bacteria. Antimicrob Agents Chemother. 1977 Nov;12(5):609-13. [3]. E Bergogne-Bérézin. Continuous Activity of Significant Antibiotics. Clin Ther. Jan-Feb 1991;13(1):181-8.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.52 g/cm3
Boiling Point	761.8ºC at 760mmHg
Melting Point	236.5°C (rough estimate)
Molecular Formula	C₁₈H₁₉N₃O₆S
Molecular Weight	405.42500
Flash Point	414.5ºC
Exact Mass	405.09900
PSA	164.33000
LogP	1.01720
Index of Refraction	1.678
InChIKey	FUBBGQLTSCSAON-PBFPGSCMSA-N
SMILES	CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccccc3)C2SC1

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XI0345000

CHEMICAL NAME :: 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(2-amino-2-phenylacetamido)- 3-(hydroxymethyl)-8-oxo-, acetate (ester), D-

CAS REGISTRY NUMBER :: 3577-01-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H19-N3-O6-S

MOLECULAR WEIGHT :: 405.46

WISWESSER LINE NOTATION :: T46 ANV EM GUTJ CMVYZR& G1OV1 HVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2800 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Liver - other changes

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1030 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,22,1970 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1200 mg/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,39,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 12 gm/kg

SEX/DURATION :: female 7-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: NKRZAZ Chemotherapy (Tokyo). (Nippon Kagaku Ryoho Gakkai, 2-20-8 Kamiosaki, Shinagawa-Ku, Tokyo 141, Japan) V.1- 1953- Volume(issue)/page/year: 18,39,1970

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xn
Risk Phrases	42/43
Safety Phrases	36

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

H-D-Phg-OMe．HCl

CAS#:19883-41-1

7-Aminocephalos...

CAS#:957-68-6

Cefaloglycin

CAS#:3577-01-3

Learn More

Literature: Ogasa; Saito; Hashimoto; Sato; Hirata Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 2 p. 315 - 321

(6R)-3-acetoxym...

CAS#:7765-60-8

Cefaloglycin

CAS#:3577-01-3

Learn More

Literature: Spencer; Flynn; Roeske; Siu; Chauvette Journal of medicinal chemistry, 1966 , vol. 9, # 5 p. 746 - 750

Boc-D-Phg-OH

CAS#:33125-05-2

Cefaloglycin

CAS#:3577-01-3

Learn More

Literature: Spencer; Flynn; Roeske; Siu; Chauvette Journal of medicinal chemistry, 1966 , vol. 9, # 5 p. 746 - 750

methyl (R)-amin...

CAS#:24461-61-8

7-Aminocephalos...

CAS#:957-68-6

Cefaloglycin

CAS#:3577-01-3

Learn More

Literature: Kawamori; Hashimoto; Katsumata; et al. Agricultural and Biological Chemistry, 1983 , vol. 47, # 11 p. 2503 - 2509

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:19883-41-1 H-D-Phg-OMe．HCl CAS#:957-68-6 7-Aminocephalos... CAS#:7765-60-8 (6R)-3-acetoxym... CAS#:33125-05-2 Boc-D-Phg-OH
CAS#:24461-61-8 methyl (R)-amin...
DownStream 0

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Antibacterial activity against Escherichia coli after 18 hrs by serial dilution metho...
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL3253338

Name: Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea...
Source: ChEMBL
Target: Gamma-aminobutyric acid receptor subunit alpha-1
External Id: CHEMBL5291800

Name: Antibacterial activity against beta-lactamase producing benzylpenicillin-resistant St...
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL3253337

Name: Antibacterial activity against Shigella sonnei after 18 hrs by serial dilution method
Source: ChEMBL
Target: Shigella sonnei
External Id: CHEMBL3253340

Name: Antibacterial activity against Salmonella typhi after 18 hrs by serial dilution metho...
Source: ChEMBL
Target: Salmonella enterica subsp. enterica serovar Typhi
External Id: CHEMBL3253339

Name: Antibacterial activity against Proteus mirabilis after 18 hrs by serial dilution meth...
Source: ChEMBL
Target: Proteus mirabilis
External Id: CHEMBL3253342

Name: Antibacterial activity against Klebsiella aerogenes after 18 hrs by serial dilution m...
Source: ChEMBL
Target: Klebsiella aerogenes
External Id: CHEMBL3253341

Name: Drug level in mouse blood at 50 mg/kg, po after 10 mins by microbiological assay
Source: ChEMBL
Target: Blood
External Id: CHEMBL3253344

Name: Drug level in mouse blood at 50 mg/kg, po after 30 mins by microbiological assay
Source: ChEMBL
Target: Blood
External Id: CHEMBL3253346

Name: Binding affinity towards human ESR1 in an in vitro cell free assay (CRO assay) measur...
Source: ChEMBL
Target: Estrogen receptor
External Id: CHEMBL5291792

Total 78, Current Page 1 of 8

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Cefaloglycin

Cephaloglycine

(6R)-3-acetoxymethyl-7t-((R)-2-amino-2-phenyl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cephaoglycin acid

(6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefaloglycine

Cefaloglicina

CEPHALOGLYCIN

D-Cephaloglycine

Kafocin

Cefaloglycinum

Cephaloglycin anhydrous

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of cefaloglycin?

A: LogP of cefaloglycin is 1.01720.

Q: What is the polar surface area (PSA) of cefaloglycin?

A: Polar surface area (PSA) of cefaloglycin is 164.33000.

Q: What is the English name of cefaloglycin?

A: The English name of cefaloglycin is cefaloglycin.

Q: What are the uses of cefaloglycin?

A: Main uses of cefaloglycin: Cefaloglycin (Cephaloglycin) is an orally active nephrotoxic β-lactam cephalosporin antibiotic with antibacterial activity. Cefaloglycin is activity against Gram-Positive cocci other than enterococci. Cefaloglycin is toxic to mitochondrial substrate uptake and respiration[1][2][3].

Q: What English synonyms does cefaloglycin have?

A: English synonyms of cefaloglycin: Cefaloglycin, Cephaloglycine, (6R)-3-acetoxymethyl-7t-((R)-2-amino-2-phenyl-acetylamino)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Cephaoglycin acid, (6R,7R)-3-(acetyloxymethyl)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, Cefaloglycine, Cefaloglicina, CEPHALOGLYCIN, D-Cephaloglycine, Kafocin, Cefaloglycinum, Cephaloglycin anhydrous.

Q: What is the SMILES notation of cefaloglycin?

A: SMILES notation of cefaloglycin is CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(N)c3ccccc3)C2SC1.

Q: What are the upstream materials of cefaloglycin?

A: Related upstream materials(CAS) of cefaloglycin: 19883-41-1;957-68-6;7765-60-8;33125-05-2;24461-61-8.

Q: What is the boiling point of cefaloglycin?

A: Boiling point of cefaloglycin is 761.8ºC at 760mmHg.

Q: What is the molecular weight of cefaloglycin?

A: Molecular weight of cefaloglycin is 405.42500.

Q: What is the molecular formula of cefaloglycin?

A: Molecular formula of cefaloglycin is C18H19N3O6S.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Dayang Chem (Hangzhou) Co., Ltd.

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Product Name: Palmitic acid
Price: Check
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: cefaloglycin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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