EMI1

• 常用名: EMI1
• 英文名: EMI1
• CAS号: 35773-42-3
• 分子量: 334.36900
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈N₂O₃
• 熔点: N/A
• 闪点: N/A

EMI1用途

EMI1 是 EGFR 三重突变体 EGFR ex19del/T790M/C797S 和 EGFR L858R/T790M/C797S 的有效抑制剂。

EMI1名称

• 英文名: 3-(2-benzoxazolyl)-7-(diethylamino)-2H-1-benzopyran-2-one

EMI1生物活性

• 描述: EMI1 是 EGFR 三重突变体 EGFR ex19del/T790M/C797S 和 EGFR L858R/T790M/C797S 的有效抑制剂。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 靶点实验:

  EGFRdel19 T790M C797S

  EGFRL858R/T790M/C797S

• 体外研究: EMI1抑制PC9-EGFR-ex19del/T790M/C797S类器官生长,EC50为131nm[1]。EMI1(1nm-10μM)能有效降低EGFR三重突变体与Shc1的相互作用[1]。EMI1(1nm-100μM)对PC9 EGFR ex19del/T790M/C797S三重突变体细胞的生存能力和caspase 3/7活性的抑制作用强于非癌人支气管上皮(HBE)细胞[1]。支气管上皮细胞活性测定[t7wt/EGFR-791细胞株]pchbr-791/EGFR。浓度：0.001、0.01、0.1、1、10、100μM孵育时间：72h结果：对活力有较强的抑制作用。
• 参考文献:

  [1]. Punit Saraon, et al. A drug discovery platform to identify compounds that inhibit EGFR triple mutants. Nat Chem Biol. 2020 May;16(5):577-586.

EMI1物理化学性质

• 分子式: C₂₀H₁₈N₂O₃
• 分子量: 334.36900
• 精确质量: 334.13200
• PSA: 59.48000
• LogP: 4.44740
• InChIKey: UJOQSHCJYVRZKJ-UHFFFAOYSA-N
• SMILES: CCN(CC)c1ccc2cc(-c3nc4ccccc4o3)c(=O)oc2c1
• 储存条件: -20°C，密闭，干燥

EMI1安全信息

• 海关编码: 2934999090

EMI1海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

EMI1靶点实验

查看更多实验

实验名称：Antiproliferative activity against human DLD1 cell line 来源：ChEMBL 靶标：DLD-1 External Id：CHEMBL855865

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Antiproliferative activity against human SiHa cell line 来源：ChEMBL 靶标：SiHa External Id：CHEMBL855866

实验名称：Antiproliferative activity against mouse NIH3T3 cell line 来源：ChEMBL 靶标：NIH3T3 External Id：CHEMBL855867

实验名称：Chemical Probes of Kaposi's Sarcoma Herpes Virus Latent Infection 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：ORF 73 [Human herpesvirus 8 type M] External Id：HMS791

实验名称：Antiproliferative activity against HUVEC cell line 来源：ChEMBL 靶标：HUVEC External Id：CHEMBL855869

实验名称：Inhibition of mRNA splicing of human SMN2 exon 7 transfected in HEK293H cells assesse... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4478610

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

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EMI1英文别名

• 3-benzooxazol-2-yl-7-diethylamino-chromen-2-one
• 3-(1,3-BENZOXAZOL-2-YL)-7-(DIETHYLAMINO)-2H-CHROMEN-2-ONE