Relaxin H2 (human) trifluoroacetate salt
Modify Date: 2025-10-23 18:31:55
Relaxin H2 (human) trifluoroacetate salt structure
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Common Name | Relaxin H2 (human) trifluoroacetate salt | ||
|---|---|---|---|---|
| CAS Number | 99489-94-8 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | N/A | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Relaxin H2 (human) trifluoroacetate saltSerelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity[1][2][3]. |
| Name | Serelaxin |
|---|
| Description | Serelaxin (RLX-030), a recombinant form of human gene-2 relaxin targeting the RLN receptor, is a vasoactive peptide hormone with an antifibrotic activity[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vivo | Serelaxin (0.5 mg/kg per day, subcutaneous administration) produces 20 to 40 ng/mL of circulating hormone, which successfully prevents and reduces fibrosis progression in various experimental models of injury. The doses do not exhibit significant toxicity[1]. Serelaxin restores endothelial function by increasing nitric oxide (NO)-mediated relaxation but not endothelium-derived hyperpolarisation (EDH)[2]. Animal Model: Six- to 8-week-old male mice (on a 129sv or 129sv×C57B6J background, which were equally sensitive to tissue injury and fibrosis)[1]. Dosage: 0.5 mg/kg. Administration: Subcutaneous administration per day for 7 days. Result: Produced 20 to 40 ng/mL of circulating hormone. |
| References |
[3]. Serelaxin. |
| InChIKey | DTLOVISJEFBXLX-REAFJZEQSA-N |
|---|---|
| SMILES | CCC(C)C1NC(=O)C(C)NC(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)C(NC(=O)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCSC)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(CO)NC(=O)C(N)CC(=O)O)C(C)C)C(C)CC)CSSCC2NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CC(N)=O)NC(=O)C(C)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(CC(C)C)NC(=O)C3CCC(=O)N3)CSSCC(NC(=O)CNC(=O)C(C(C)C)NC(=O)C(Cc3cnc[nH]3)NC2=O)C(=O)NC(C(C)O)C(=O)NC(CCCCN)C(=O)NC(CCCNC(=N)N)C(=O)NC(CO)C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc2ccccc2)C(=O)NC(C(=O)O)CSSCC(C(=O)NCC(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CO)C(=O)O)C(C)O)NC1=O |
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