Piribedil

Modify Date: 2026-07-17 07:31:45

Piribedil structure	Common Name	Piribedil
	CAS Number	3605-01-4	Molecular Weight	298.340
	Density	1.3±0.1 g/cm3	Boiling Point	469.4±55.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₈N₄O₂	Melting Point	98 °C
	MSDS	N/A	Flash Point	237.7±31.5 °C

Use of Piribedil

Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR).

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Piribedil is a dopamine D2 receptor (D2R) agonist which also displays antagonist property at hα1A-adrenoceptor (hα1A-AR).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	D2R, hα1A-AR[1]
References	[1]. Mark J. Milla, et al. Antiparkinsonian Agent Piribedil Displays Antagonist Properties at Native, Rat, and Cloned, Human α2 -Adrenoceptors: Cellular and Functional Characterization. JPET, 2001, 297 (3) 876-887.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.3±0.1 g/cm3
Boiling Point	469.4±55.0 °C at 760 mmHg
Melting Point	98 °C
Molecular Formula	C₁₆H₁₈N₄O₂
Molecular Weight	298.340
Flash Point	237.7±31.5 °C
Exact Mass	298.142975
PSA	50.72000
LogP	2.36
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.632
InChIKey	OQDPVLVUJFGPGQ-UHFFFAOYSA-N
SMILES	c1cnc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1
Storage condition	2-8°C

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Piribedil MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UV9704000

CHEMICAL NAME :: Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-

CAS REGISTRY NUMBER :: 3605-01-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H18-N4-O2

MOLECULAR WEIGHT :: 298.38

WISWESSER LINE NOTATION :: T56 BO DO CHJ G1- AT6N DNTJ D- BT6N CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1460 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 690 mg/kg

TOXIC EFFECTS :: Vascular - regional or general arteriolar or venous dilation Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,1151,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 88 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967- Volume(issue)/page/year: 6,75,1969

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Hazard Codes	Xi
HS Code	2934999090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

Piperonyl alcohol

CAS#:495-76-1

1-(2-PYRIMIDINY...

CAS#:20980-22-7

~99%

Piribedil

CAS#:3605-01-4

Learn More

Literature: Peishan, Siah; Dang, Tuan Thanh; Seayad, Abdul Majeed; Ramalingam, Balamurugan ChemCatChem, 2014 , vol. 6, # 3 p. 808 - 814

piperonal

CAS#:120-57-0

1-(2-PYRIMIDINY...

CAS#:20980-22-7

~74%

Piribedil

CAS#:3605-01-4

Learn More

Literature: Duncton, Matthew A. J.; Roffey, Jonathan R. A.; Hamlyn, Richard J.; Adams, David R. Tetrahedron Letters, 2006 , vol. 47, # 15 p. 2549 - 2552

piperonal

CAS#:120-57-0

1-(2-PYRIMIDINY...

CAS#:20980-22-7

~54%

4-pyrimidin-2-y...

CAS#:88268-16-0

Piribedil

CAS#:3605-01-4

Learn More

Literature: Chilmonczyk; Cybulski; Krajewski; Szelejewski Archiv der Pharmazie, 1993 , vol. 326, # 4 p. 241 - 242

Formic Acid

CAS#:64-18-6

1-(2-PYRIMIDINY...

CAS#:20980-22-7

~54%

4-pyrimidin-2-y...

CAS#:88268-16-0

Piribedil

CAS#:3605-01-4

Learn More

Literature: Chilmonczyk; Cybulski; Krajewski; Szelejewski Archiv der Pharmazie, 1993 , vol. 326, # 4 p. 241 - 242

tert-Butyl 4-(p...

CAS#:780705-64-8

Piribedil

CAS#:3605-01-4

Learn More

Literature: Tetrahedron Letters, , vol. 47, # 15 p. 2549 - 2552

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 5
CAS#:495-76-1 Piperonyl alcohol CAS#:20980-22-7 1-(2-PYRIMIDINY... CAS#:120-57-0 piperonal CAS#:64-18-6 Formic Acid
CAS#:780705-64-8 tert-Butyl 4-(p...
DownStream 0

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine

2-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)pyrimidine

Piribedilum [INN-Latin]

1-(2''-Pyrimidyl)-4-(methylene-3',4'-dioxybenzyl)piperazine

2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-pyrimidine

Piribedile [DCIT]

3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine

2-[4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine

Piribedil

ET 495

Trivastal

MFCD00868264

Trivastan

EU-4200

EINECS 222-764-6

2-[4-(3,4-Methylenedioxybenzyl)piperazino]pyrimidine

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the SMILES notation of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: SMILES notation of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is c1cnc(N2CCN(Cc3ccc4c(c3)OCO4)CC2)nc1.

Q: What is the LogP of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: LogP of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 2.36.

Q: What is the boiling point of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: Boiling point of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 469.4±55.0 °C at 760 mmHg.

Q: What is the InChIKey of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: InChIKey of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is OQDPVLVUJFGPGQ-UHFFFAOYSA-N.

Q: What is the polar surface area (PSA) of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: Polar surface area (PSA) of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 50.72000.

Q: What is the molecular formula of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: Molecular formula of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is C16H18N4O2.

Q: What is the CAS number of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: CAS number of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 3605-01-4.

Q: What is the molecular weight of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: Molecular weight of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 298.340.

Q: What is the melting point of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: Melting point of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 98 °C.

Q: What is the English name of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine?

A: The English name of 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine is 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Palmitic acid
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]pyrimidine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Piribedil
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

Piribedil suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more Piribedil price

Piribedil

Use of Piribedil

Names

Piribedil Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Synonyms

Piribedil | FAQ

Piribedilfactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.