Tramiprosate

Modify Date: 2024-01-02 12:56:30

Tramiprosate Structure
Tramiprosate structure
 Common Name Tramiprosate
CAS Number 3687-18-1 Molecular Weight 139.173
Density 1.4±0.1 g/cm3 Boiling Point N/A
Molecular Formula C3H9NO3S Melting Point 293 °C (dec.)(lit.)
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Tramiprosate


Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.

 Names

Name 3-Amino-1-propanesulfonic acid
Synonym More Synonyms

 Tramiprosate Biological Activity

Description Tramiprosate is a small, orally-administered compound that binds to soluble Aβ and reduces amyloid aggregation and subsequent depositiontarget: AβIn vitro: Tramiprosate provides neuroprotection against Aβ-induced neurotoxicity in neuronal and mouse organotypic hippocampal cultures, and reverses Aβ-induced long-term potentiation (LTP) inhibition in rat hippocampus, in part, through activation of β-aminobutyric acid A (GABA-A) receptors. Tramiprosate dose-dependently provides neuroprotection against ischemic stroke.In vivo: Tramiprosate produced dose-dependent reductions of Aβ in the brain of transgenic mice (hAPP-TgCRND8). Clinical studies show that tramiprosate was safe and tolerable. In mild-to-moderate AD patients tramiprosate also reduced Aβ42 levels in CSF.The reference for animal administration is 50 mg/kg.
Related Catalog
References

[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.

[2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer's disease - a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Melting Point 293 °C (dec.)(lit.)
Molecular Formula C3H9NO3S
Molecular Weight 139.173
Exact Mass 139.030319
PSA 88.77000
LogP -2.25
Index of Refraction 1.508
Storage condition Store at 0-5°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 1
HS Code 2921199090

 Synthetic Route

 Customs

HS Code 2921199090
Summary 2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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 Synonyms

1-Propanesulfonic acid, 3-amino-
tramiprosate
Homotaurine
3-aminopropane-1-sulfonic acid
Alzhemed
3-Aminopropane sulfonic acid
3-Amino-1-propanesulfonic acid
3-aminopropane-1-sulphonic acid
3-Amino-propane-1-sulfonic acid
3-APS
EINECS 222-977-4
MFCD00008225
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Chemsrc provides Tramiprosate(CAS#:3687-18-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tramiprosate are included as well.>> amp version: Tramiprosate

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