Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

Modify Date: 2024-01-04 14:21:13

Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1) structure	Common Name	Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)
	CAS Number	3724-89-8	Molecular Weight	179.11000
	Density	1.597g/cm3	Boiling Point	384.2ºC at 760mmHg
	Molecular Formula	C₂H₇NNaO₃PS	Melting Point	220ºC (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	186.2ºC
	Symbol	GHS07	Signal Word	Warning

Use of Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant[1][2].

Name	sodium,2-aminoethylsulfanyl(hydroxy)phosphinate
Synonym	More Synonyms

Description	Cysteamine S-phosphate (Cystaphos) sodium can be hydroIyzed to Cysteamine by human alkaline phosphatases. Cysteamine is an orally active agent for the research of nephropathic cystinosis and an antioxidant[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Gainer AL, et al. Cysteamine S-phosphate hydrolysis by pure human alkaline phosphatases and by sera from patients with lymphoproliferative disorders. Cancer Res. 1982 Sep;42(9):3507-9. [2]. Besouw M, et al. Cysteamine: an old drug with new potential. Drug Discov Today. 2013 Aug;18(15-16):785-92.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

References

[1]. Gainer AL, et al. Cysteamine S-phosphate hydrolysis by pure human alkaline phosphatases and by sera from patients with lymphoproliferative disorders. Cancer Res. 1982 Sep;42(9):3507-9.

[2]. Besouw M, et al. Cysteamine: an old drug with new potential. Drug Discov Today. 2013 Aug;18(15-16):785-92.

Density	1.597g/cm3
Boiling Point	384.2ºC at 760mmHg
Melting Point	220ºC (dec.)(lit.)
Molecular Formula	C₂H₇NNaO₃PS
Molecular Weight	179.11000
Flash Point	186.2ºC
Exact Mass	178.97800
PSA	121.49000
LogP	0.90950

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TE6483500

CHEMICAL NAME :: Phosphorothioic acid, S-(2-aminoethyl) ester, monosodium salt

CAS REGISTRY NUMBER :: 3724-89-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C2-H7-N-O3-P-S.Na

MOLECULAR WEIGHT :: 179.12

WISWESSER LINE NOTATION :: Z2SPQO&O &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 555 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 505 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1433 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 806 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1003 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 358 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

REFERENCE :: RADOA8 Radiobiologiya. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1961- Volume(issue)/page/year: 16,249,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22-36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TE6483500

A comparison of the effectiveness of cysteamine and phosphocysteamine in elevating plasma cysteamine concentration and decreasing leukocyte free cystine in nephropathic cystinosis.

Pediatr. Res. 23(6) , 616-20, (1988)

Cysteamine (beta-mercaptoethylamine, MEA) is currently used to treat children with nephropathic cystinosis. In this study MEA was compared to phosphocysteamine (MEAP), a phosphorothioester that tastes...

The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire.

Pediatr. Nephrol. 9(6) , 685-9, (1995)

Fifty-nine patients with cystinosis were treated with cysteamine or phosphocysteamine in the United Kingdom up to May 1990. Treatment was started at a median age of 3.2 years (range 0.6-24.8 years) an...

Combination small molecule PPT1 mimetic and CNS-directed gene therapy as a treatment for infantile neuronal ceroid lipofuscinosis.

J. Inherit. Metab. Dis. 35(5) , 847-57, (2012)

Infantile neuronal ceroid lipofuscinosis (INCL) is a profoundly neurodegenerative disease of children caused by a deficiency in the lysosomal enzyme palmitoyl protein thioesterase-1 (PPT1). There is c...

Phosphocysteamine

Tsistafos

MFCD00038474

Cystaphos sodium salt

Tsistafos (cystafos)

Cystaphos

Cistaphos

S-(2-Aminoethyl) thiophosphate monosodium salt

EINECS 223-079-5

Cystafos

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)
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Purity: 98.0%
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Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

Use of Ethanethiol, 2-amino-,1-(dihydrogen phosphate), sodium salt (1:1)

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